Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

Diastolic Heart Failure Clinical Trial

Official title:

Diagnostic Value of Measures of Pulsatile Versus Steady State Hemodynamics in Diastolic Heart Failure

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00720525
• Other study ID #: EK 248
• Status: Completed
• Phase: N/A
• First received: July 18, 2008
• Last updated: July 15, 2011
• Start date: April 2008
• Est. completion date: July 2011

Study information

• Verified date: July 2011
• Source: Klinikum Wels-Grieskirchen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria: Ethikkommission
• Study type: Observational

Clinical Trial Summary

Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD). Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, the investigators speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 362
• Est. completion date: July 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• exertional dyspnea

• undergoing heart catheterization for diagnosis or exclusion of coronary artery disease

• normal EF (> 50%)

Exclusion Criteria:

• atrial fibrillation

• more than mild valvular heart disease

• pericardial disease

• no informed consent

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Diastolic Heart Failure
• Heart Failure
• Heart Failure, Diastolic

Locations

Country	Name	City	State
Austria	Cardiology Department, Klinikum Wels-Grieskirchen	Wels

Sponsors (1)

Lead Sponsor	Collaborator
Klinikum Wels-Grieskirchen

Country where clinical trial is conducted

Austria,