Diabetes Mellitus, Type 2 Clinical Trial
Official title:
A Longitudinal Cohort Study to Identify Clinical and Blood Markers of Early Pancreas Cancer
Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an individual's chance of surviving the disease. The investigators propose a longitudinal study of subjects at higher than average risk of PDAC in order to generate clinical data and bank serial blood specimens.
Status | Recruiting |
Enrollment | 1250 |
Est. completion date | July 2028 |
Est. primary completion date | July 2028 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 19 Years and older |
Eligibility | Inclusion Criteria: General inclusion criteria: 1. Age =19 2. Able to provide written, informed consent 3. Able to to attend an in-person study visit in Omaha, NE twice a year to collect blood samples Exclusion Criteria: General exclusion criteria: 1. Personal history of PDAC 2. Currently receiving treatment for a cancer diagnosis (excluding long-term hormonal therapy) 3. Pre-diabetes on metformin for = 3 years |
Country | Name | City | State |
---|---|---|---|
United States | Unversity of Nebraska Medical Center | Omaha | Nebraska |
Lead Sponsor | Collaborator |
---|---|
University of Nebraska | National Cancer Institute (NCI), VA Nebraska Western Iowa Health Care System, Virginia Mason Hospital/Medical Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of pancreas cancer cases diagnosed. | Number of pancreas cancer cases diagnosed. | 10 years | |
Primary | Biomarkers which may predict early pancreas cancer. | Biomarkers which may predict early pancreas cancer. | 10 years | |
Primary | Result of MMTT which may indicate type 3c diabetes, which may be a risk factor for pancreas cancer. | Result of MMTT which may indicate type 3c diabetes, which may be a risk factor | 10 years |
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