Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Cross-Sectional Study on Association Between the Estimation of Insulin Resistance and Beta Cell Function Through Homeostasis Model Assessment With HbA1C Among Oral Anti-Diabetics Treatment Non-Responders
Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced. Insulin resistance and beta cell function will be estimated through a mathematical model, homeostasis model assessment. Fasting insulin and C-peptide will be measured using liquid chromatography tandem mass spectrometry. Insulin resistance and beta cell function is then compared with the glycaemic control, HbA1C.
Primary objective
• To investigate the association between the estimation of insulin resistance and beta cell
function through homeostasis model assessment with HbA1C among oral anti-diabetics treatment
non-responder.
Secondary Objectives
- To compare the insulin resistance and beta cell function between the OAD treatment
responders (negative control) and non-responders
- To investigate the relationship between plasma level of metformin and gliclazide with
the estimation of beta cell function and insulin resistance
- To identify the proportion of patients with high insulin resistance and proportion of
patients with low beta cell function
- To identify difference in insulin resistance and beta cell function of different ethnic
groups in Sarawak
- To compare insulin resistance with cardiovascular disease risk using Framingham Risk
Score and ASCVD risk estimation
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