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Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension — SPIRY  

Diabetes Mellitus Clinical Trial

Official title:
Prevalence and Treatment of Resistant Hypertension in Diabetic Patients in Yaounde

Clinical Trial Summary

This is a four-week randomized controlled single blinded trial of subjects presenting with resistant hypertension in a specialized diabetes care unit of Cameroon. They are randomly assigned using the method of blocks to treatment with a daily 25mg of spironolactone or to routine intensification of antihypertensive regimen , all added to previous regimen with unchanged diet. Visits are scheduled at the start of the treatment, at weeks two and four following add-on therapy initiation. The primary outcome is change in office and self-measurement blood pressure recorded at each visit, and secondary outcomes are variations in serum potassium, sodium, and creatinine levels.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02426099
Study type Interventional
Source Yaounde Central Hospital
Contact
Status Completed
Phase Phase 4
Start date October 2011
Completion date October 2012
View Details
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