Insulin Resistance And End Stage Renal Disease: The Role Of Retinol Binding Protein 4

Diabetes Clinical Trial

Official title:

Insulin Resistance And End Stage Renal Disease: The Role Of Retinol Binding Protein 4

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00910130
• Other study ID #: RBP4
• Status: Recruiting
• Phase: N/A
• First received: May 28, 2009
• Last updated: May 28, 2009
• Start date: July 2008

Study information

• Verified date: May 2009
• Source: IRCCS Policlinico S. Matteo
• Contact: Giovanni Piotti, MD
• Phone: +390382502590
• Email: gpiotti[@]yahoo.it
• Is FDA regulated: No
• Health authority: Italy: National Bioethics Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to determine whether Retinol binding protein 4 has a role in insulin resistance development in patients suffering from end stage renal disease on hemodialysis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Hemodialysis for "End Stage Renal Disease group"

• Normal Renal Function for "Control group"

Exclusion Criteria:

• Diabetes

• Malnutrition

• Malignancy

• Acute Infection

• Chronic Active Infection

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Diabetes
• End Stage Renal Disease
• Insulin Resistance
• Kidney Diseases
• Kidney Failure, Chronic

Locations

Country	Name	City	State
Italy	Giovanni Piotti	Pavia

Sponsors (1)

Lead Sponsor	Collaborator
IRCCS Policlinico S. Matteo

Country where clinical trial is conducted

Italy, 

References & Publications (2)

Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006 Jun 15;354(24):2552-63. — View Citation

Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005 Jul 21;436(7049):356-62. — View Citation