The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients

Diabetes Mellitus, Type 2 Clinical Trial

Official title:

The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients, Special Relevance to Atherosclerosis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00155922
• Other study ID #: 9261700953
• Status: Recruiting
• Phase: N/A
• First received: September 9, 2005
• Last updated: December 13, 2006
• Start date: November 2003

Study information

• Verified date: September 2005
• Source: National Taiwan University Hospital
• Contact: Wei-Shiung Yang, MD, PhD
• Phone: 886-2-2312-3456
• Email: wsyang[@]ha.mc.ntu.edu.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

The investigators hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).

Description:

Cardiovascular events are the leading cause of death in developed countries worldwide, including Taiwan. Type 2 diabetes mellitus (T2DM), previously considered merely as one of the risk factors, has been recently unanimously accepted to be coronary artery disease-equivalent. How T2DM may lead to accelerated atherosclerosis remains obscure.

Hyperglycemia with or without hyperinsulinemia may lead to higher oxidative stress and generalized inflammation. The oxidative stress and inflammation may play a significant role in the pathogenesis in diabetic complications, including micro- and macro-vascular complications. Macrophages together with T-lymphocytes are the earliest cell-types found in fatty-streaks, the earliest atherosclerotic lesions. Macrophages are also well known cellular mediators of oxidative stress and inflammation. Therefore, it is plausible to hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with T2DM. In addition, the other cell types of the peripheral white blood cells (WBC), such as neutrophils, have been shown to be intimately related to acute coronary syndrome. Therefore, the study on the biology of peripheral WBCs may tell us something about the pathophysiology of diabetic macro-vascular complications.

Methods:

1. Normal control: fasting plasma glucose (FPG) less than 126 mg/dl.

2. T2DM: FPG ＞＝126 mg/dl.

• Group 1 (good glycemic control): hemoglobin A1c (HbA1c) ＜＝ 7% in the past 6 months

• Group 2 (poor glycemic control): HbA1c ＞＝ 8% in the past 6 months

3. Blood sample will be collected at baseline and after aggressive control.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 25 Years to 65 Years

Eligibility

Inclusion Criteria:

• Normal control: fasting plasma glucose (FPG) less than 126 mg/dl.

• T2DM: FPG >=126 mg/dl.

• Group 1 (good glycemic control): HbA1c<=7% in the past 6 months

• Group 2 (poor glycemic control): HbA1c>=8% in the past 6 months

Exclusion Criteria:

• Acute systemic diseases

Study Design

Observational Model: Case Control, Time Perspective: Longitudinal

Related Conditions & MeSH terms

• Atherosclerosis
• Diabetes Mellitus
• Diabetes Mellitus, Type 2

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan,