Diabetes Mellitus, Type 2 Clinical Trial
Official title:
A Trial Investigating the Effect of Probenecid and Ciclosporin on the Pharmacokinetics of SNAC in Healthy Subjects
The aim of the study is to investigate the effect of the medicines, probenecid and
ciclosporin on the concentrations of SNAC. SNAC is an ingredient of the semaglutide tablets.
Participants will get 3 different treatments (that is 3 treatment periods): 1) a single dose
of 3 mg semaglutide, 2) a single dose of 600 mg ciclosporin with 3 mg semaglutide, 3) 500 mg
probenecid twice a day for 3 ½ days with a single dose of 3 mg semaglutide on the last day.
The sequence of treatments participants get is decided by chance. Probenecid and ciclosporin
are available medicines. They are given by doctors. Semaglutide contains SNAC. It cannot be
prescribed yet.
The study will last for up to 125 days. Participants will have 17 to 18 visits at the study
centre. This includes short visits at the centre for blood sampling only. Participants will
have several blood draws.
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