Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Functional MRI Biomarkers of Cognitive Decrements in Diabetes
The exact neuronal mechanism underlying the cognitive decline associated with diabetes mellitus type 2 (DM2) still remains to be elucidated. Multi-parametric functional MRI can potentially provide functional, micro-structural, micro-vascular, and metabolic information on the affected brain at an earlier stage than does conventional structural MRI. The overall aim of the current proposal is to obtain a better understanding in the neuronal mechanisms that underlie cognitive decline in DM2 and the putative prediabetic condition the metabolic syndrome (MetS).
Diabetes mellitus type 2 (DM2) is a common chronic metabolic disorder that affects 4.1% of
the Dutch population. In addition to vascular disease, DM2 is associated with structural
brain changes visible on MRI, accelerated cognitive decline, and dementia in older
individuals. The exact pathophysiological mechanisms underlying cognitive decrements in DM2
still remain to be elucidated. The 'metabolic syndrome' (MetS), defined as a cluster of
cardiovascular risk factors (including obesity, hypertension, and dyslipidemia) is often
considered a prediabetic condition. Individuals with MetS display similar cognitive
decrements as do DM2 patients, but do not share the severity of brain injury. It has been
indicated that in prediabetic MetS, cognitive problems precede structural brain changes, and
that MetS and DM2 affect the brain through a shared mechanism in which vascular co-morbidity
is essential.
The primary objectives are defined according to a hierarchical design: i) to tailor and
apply multi-parametric, functional MRI techniques to identify cerebral abnormalities
(cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral biomarkers are
shared and differ between DM2 and MetS; iii) to assess whether these cerebral biomarkers are
associated with cognitive decrements.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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