Diabete Type 2 Clinical Trial
Official title:
Assessment of Vascular and Metabolic Changes in Post-menopausal Women With Type 2 Diabetes Mellitus
The presence of type 2 diabetes mellitus (T2DM) also increases the relative risk of developing cardiovascular disease in women compared to men. Carotid intima media thickness (IMTc) was increased with reduction in brachial artery flow-mediated dilation (FMD) in T2 DM patients and inversely and strongly related to the extent of hyperglycemia. Low concentrations of folate and vitamin B12 involved in homocysteine metabolism are also associated with increased risk of vascular damage. the aim is to relate, if found, the degree of metabolic changes to the extent in vascular parameters changes in type 2 diabetic postmenopausal women.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | November 15, 2018 |
Est. primary completion date | October 10, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 50 Years to 70 Years |
Eligibility |
Inclusion Criteria: - post-menopausal women - aged 50-70 years - amenorrhea for over 24 months. - The diabetic participants will receive their treatment for T2DM (oral hypoglycemic agents or insulin). Exclusion Criteria: - Patients receiving hormone replacement therapy. - History of abnormal vaginal bleeding. - Patients receiving vitamin B12, vitamin D and folic acid regularly. - History of malignancy or neurological diseases as epilepsy, parkinsonism and Alzheimer disease. - Antifolate medications as methotrexate are excluded from the study. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | metabolic changes in type 2 diabetes | changes in folate level in type 2 diabetes mellitus | baseline and 3 months | |
Primary | metabolic changes in type 2 diabetes | B12 level and their relation to complications | baseline and 3 months |
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