Dexmedetomidine in Obturator Nerve Block as an Analgesic in Transurethral

Status Recruiting

Clinical Trial Summary

in our study, we will investigate the impact of adding dexmedetomidine to bupivacaine for the potency of the obturator nerve block and prevention of the postoperative pain associated with transurethral surgery in comparison of obturator nerve block with bupivacaine alone

Clinical Trial Description

- After history taking and examination of the labs and airway of the patient , An intravenous catheter will be secured in the dorsum of the hand of non dominant hand and patients will be monitored for heart rate, noninvasive blood pressure, and oxygen saturation. - All patients after aseptic preparation will receive subarachnoid block in lumber 3-4 or 4-5 space in sitting position. - About 3 ml (15mg) of heavy 0.5% bupivacaine will be injected into subarachnoid space. - After the completion of the block, patients will be laid in the supine position and subsequently waited for 5 min for fixation of drug and assessed for sensorimotor block. - Further procedure will be performed as per the group allocation. - ONB will be performed by classic technique 1.5cm lateral and 1.5cm caudal to the pubic tuberacle . after contact with the pubic ramus is made , the needle is redirected laterally to a point 2-3 cm deeper than the pubic ramus.(15) - A waiting period 20 min will be allowed for the full effect of the block and then resection will be allowed to perform - Hemodynamics (heart rate, mean arterial blood pressure) will be recorded intraoperatively and postoperative at 0, 2 and 6 hours . - VAS score at 0,2 and 6 hours post-operatively will be assessed. - Time to first call for analgesic requirements (duration of analgesia) will be measured. - Total postoperative analgesic consumption in the first 24 hours post-operative will be measured. - Incidence of complications such as nerve injury, hematoma formation, local anesthetic toxicity, intravascular injection, bleeding and bladder perforation will be assessed. ;

Study Design

Related Conditions & MeSH terms

Dexmedetomidine

Clinical Trial Details

NCT number	NCT06229054
Study type	Interventional
Source	Cairo University
Contact	KARIM HUSSEIN, MD
Phone	0100741161
Email	karim.ghaleb87@gmail.com
Status	Recruiting
Phase	Early Phase 1
Start date	February 1, 2024
Completion date	September 2024

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Dexmedetomidine in Obturator Nerve Block as an Analgesic in Transurethral Surgeries

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms