Clinical Trials Logo

Clinical Trial Summary

THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia. The use of high-flow nasal cannula oxygen supplementation during anesthesia for surgical procedures has been a recent development in the adult population, with limited data analyzing the pediatric population. This study will determine whether high flow nasal cannula oxygen supplementation during surgical or endoscopic procedures can safely prevent desaturation events in children under anesthesia.


Clinical Trial Description

Patients undergoing select procedures in the LPCH operating rooms or ambulatory procedure unit, as identified by review of the daily schedule will be reviewed for potential study enrollment. Study personnel will work with preoperative nurses to identify potential participants. When potential candidates are identified, the investigators will discuss with the surgeon or proceduralist and request that he/she talk with patients about study participation to introduce the idea. On the day of surgery, potential subjects will arrive to preoperative intake areas and proceed through the usual preoperative processes. Once in the preoperative intake area, potential participants will be approached by study personnel at least 30 minutes prior to their scheduled procedure for further explanation of the study and obtaining consent and assent. At this time, potential subjects will be evaluated for interval changes in health that may exclude them from the study. A random number generator will be used to enroll participants into either the usual care (control) or THRIVE (treatment) arm. Control subjects will undergo their scheduled procedure and recovery with the usual care. Treatment subjects will undergo the scheduled procedure, with the difference being that a high-flow nasal cannula will be applied prior to the start of the procedure and removed following the procedure's conclusion. While applied, the cannula will deliver high- flow rate oxygen, air, or a mixture of variable oxygen concentration (21-100%) depending on the surgical conditions and requirements. The rate will be set at 1-2L/kg/min with a maximum of 70L/min. Participants in the treatment arm will then proceed to the recovery area as usual. Following recovery from anesthesia, a brief questionnaire will be provided to applicable patients or their parents/guardians/representatives. The intraoperative vital signs and post-operative course will be analyzed with any patient data stored in a deidentified manner on Stanford- compliant encrypted devices. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03430206
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase N/A
Start date February 21, 2018
Completion date October 2, 2018

See also
  Status Clinical Trial Phase
Completed NCT02823392 - Difficult Bag Mask Ventilation and Difficult Intubation in Children
Recruiting NCT05358535 - Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial) Phase 3
Recruiting NCT05543824 - Hemodynamic Impact of Epidural Anesthesia in Relation to Age in Pediatric Patients.
Recruiting NCT03839784 - Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Completed NCT04087668 - Different Anesthetic Technique For ERCP N/A
Recruiting NCT03109119 - Does Sevoflurane Cause Genomic Damage Phase 4
Recruiting NCT04604106 - General Anesthesia Exposure and Neurodevelopmental Outcome in Pediatrics
Enrolling by invitation NCT04322994 - THRIVE Use in Pediatric Populations- Multi Site N/A
Completed NCT05383417 - No Post Intubation Laryngeal Symptoms N/A
Completed NCT03394833 - Hemodynamic Stability During Induction of Anaesthesia N/A
Completed NCT06382961 - Postoperative Dexmedetomidine in Prevention of Postoperative Delirium N/A
Not yet recruiting NCT06396000 - Factors Analysis Related to Prolonged Stay in the Pediatric Post-Anesthesia Care Unit(PACU)
Completed NCT05368415 - Comparison Between Three Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia Phase 4
Completed NCT04284644 - Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques N/A
Completed NCT03833947 - Dexamethasone vs Bicarbonate to Intracuff Lignocaine 2% in General Anaesthesia Phase 4
Recruiting NCT06390046 - Opioid-free Anesthesia, Optimization of Anesthesia After Bariatric Surgery N/A
Not yet recruiting NCT06324955 - Language During Inhalational Induction N/A
Recruiting NCT05737407 - Lung Ultrasound Guided Choice of Best Positive End-Expiratory Pressure in Neonatal Anesthesia N/A
Active, not recruiting NCT04275531 - Neurotoxicity of Anesthesia in Middle Aged Patients
Completed NCT05868642 - Impatto Emodinamico Dell'Anestesia Subaracnoidea Titrata Versus Tecnica Single-shot Nei Pazienti Sottoposti ad Artroprotesi d'Anca. RCT N/A