Depressive Symptoms Clinical Trial
Official title:
The Effects of Combination of Intravenous Dexamethasone and Ketamine on Change of Postoperative Mood in Patients Undergoing Laparoscopically Assisted Gynecologic Surgery.
Ketamine and dexamethasone have been known to be effective postoperative pain. Many studies also have reported these two drugs might change mood such as depression. This study aimed to investigate the effect of each drug individually with their combination on perioperative change of mood in patients undergoing gynecologic surgery
After receiving by IRB approval and obtaining informed consent from patients, 93 patients
who are aged between 18 and 70 years old and classified as American Society of
Anesthesiologists (ASA) classes I and II.
Afterward, the patients will be randomly (sealed envelopes) allocated into one of three
treatment; Group K (n = 31) will receive a single dose of ketamine 0.5 mg/kg i.v. plus 2 ml
normal saline, Group D (n = 31) receive dexamethasone 0.5 mg/kg i.v. and a maximum dose of 8
mg plus 2 ml saline, and Group KD (n = 31) receive ketamine 0.5 mg/kg i.v. and dexamethasone
0.5 mg/kg i.v. at 5 minutes after the induction of anesthesia in a double-blinded method.
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