Depressive Symptoms Clinical Trial
Official title:
Are Preoperative Depressive Symptoms Predictive for Postoperative Dysfunction in Non-cardiac Surgery?
Postoperative cognitive dysfunction (POCD) describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively. These changes can be resolved after weeks and months. In some cases, changes are permanent.
The aetiology of POCD is multifactorial. One described risk factor is preoperative existing
depressive symptoms in patients undergoing cardiac surgery.
A total of 300 consecutive patients and 80 healthy controls will be enrolled in this study.
Patients will be followed up at 7 days, 3 months and 1 year postoperatively. The co gnitive
function will be tested and compared to tests done before surgery. Postoperatively - from the
day of operation until the 7th day (except day 6) - grade of sedation, agitation, signs of
delirium, pain, cardiac, respiratory, renal and infectious complications will be monitored.
Next to preoperative depressive symptoms we will also evaluate a diagnosed depression,
anxiety, pain, health-related quality of life, physical comorbidities, adrenal cortical
insufficiency, type of anaesthesia, intraoperative blood loss, organ complications,
postoperative delirium, baseline cognitive functioning and the number of
operations/anaesthetics in the study period after the initial operation as further potential
predictors of POCD.
In addition, laboratory values and certain medications will be documented. These include:
anaemia, hypercalcaemia, thyroidal gland hormones, electrolytes, creatinine, urea, glomerular
filtration rate and cortisone therapy.
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