Brain Markers of Depression Vulnerability: the Case of Prefrontal Haemodynamic Response

Depression Clinical Trial

Official title:

Brain Markers of Depression Vulnerability: the Case of Prefrontal Haemodynamic Response

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05427578
• Other study ID #: HSEARS20210323001-01
• Status: Recruiting
• Start date: August 1, 2021
• Est. completion date: February 29, 2024

Study information

• Verified date: September 2023
• Source: The Hong Kong Polytechnic University
• Contact: Georg S Kranz, PhD
• Phone: 2766
• Email: georg.kranz[@]polyu.edu.hk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Functional near infrared spectroscopy (fNIRS) offers a cheap and reliable tool to investigate prefrontal brain activation in the healthy and diseased human brain. As such, fNIRS bears great potential as a diagnostic tool for clinical practice. Research indicates that fNIRS, together with a relatively simple task to activate the prefrontal cortex, the so-called verbal fluency task (VFT), elucidates prefrontal dysfunction in major depressive disorder (MDD). This finding can potentially serve as an imaging marker for disease pathology, even when depressive symptoms are absent. Indeed, recent research also suggests prefrontal dysfunction in fully remitted MDD (rMDD). Prefrontal haemodynamic responses may therefore serve as a trait marker for MDD vulnerability.

This study aims to investigate the haemodynamic response in rMDD, healthy participants with increased MDD risk (HCr; having a 1st-degree relative with MDD), and low-risk healthy participants (HCnr; having no 1st-degree relatives with MDD) using fNIRS. The investigators hypothesize lower prefrontal reactivity in HCr compared to HCnr, and lowest prefrontal reactivity in rMDD compared to HCnr.

This study has the potential to elucidate the neuronal underpinnings of depression vulnerability in the absence of symptoms that are sometimes considered a confounding factor when it comes to studying the biological encoding of depression.

Description:

Healthy participants with a high risk of MDD (HCr), healthy participants with a low risk of MDD (HCnr) and rMDD participants will be included in this study.

Prefrontal haemodynamic response will be measured in all participants during the verbal fluency test (VFT) using 52 channels fNIRS. The VFT involves two neural conditions, one positive condition, and one negative condition.

Both the neuroimage change and the behavioral outcomes of VFT will be compared within-group and among groups. The correlation between the neuroimage change and the behavioral outcomes will be analyzed as well.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: February 29, 2024
• Est. primary completion date: February 29, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Mini-mental state examination (MMSE) > 24

Exclusion Criteria:

• Current diagnosis of psychiatric disorders, such as depression, anxiety, schizophrenia, or autism

• current or past diagnosis of neurological disorders, such as head injuries, strokes, encephalitis, epilepsy, Parkinson's, or Alzheimer's

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Intervention

Other:
• fNIRS measurement
measurement using functional near-infrared spectroscopy

Locations

Country	Name	City	State
Hong Kong	The Hong Kong Polytechnic University	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Dr Georg Kranz

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Oxygenated hemoglobin (HbO) change during VFT	The HbO change during VFT measuring by fNIRS	Up to 6 months
Secondary	Deoxygenated hemoglobin (HbR) change during VFT	The HbR change during VFT measuring by fNIRS	Up to 6 months
Secondary	The VFT outcome	The number of correct words during VFT	Up to 6 months