Characterization of Suicidal Depression

Depression Clinical Trial

Official title:

Characterization of Suicidal Depression Within a Large Cohort of Inpatients: a One-year Prospective Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05046587
• Other study ID #: RECHMPL21_0395
• Status: Completed
• Start date: June 1, 2021
• Est. completion date: September 30, 2021

Study information

• Verified date: November 2021
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Antidepressants are widely used to prevent suicidal risk. However, even though the use of antidepressants has been associated with a 40-60% decrease in suicidal risk, they do not seem to be sufficient and appropriate. Indeed recent studies have shown that patients with a history of suicide attempt and/or with current suicidal ideation (SI) respond less well to antidepressant treatments. This suggests that patients with depression with SI may be different from those with depression without SI, thus requiring specific treatments for both SI reduction and depressive remission. In other words, suicidal depression may be a specific subtype of depression. The study aims to characterize the clinical phenotype of patients with suicidal depression vs. those without suicidal depression, and to assess the occurrence of suicidal events at one year in patients with suicidal depression vs. without suicidal depression. All data having already been collected during the particpation of patients in various clinical research studies of the department

Recruitment information / eligibility

• Status: Completed
• Enrollment: 898
• Est. completion date: September 30, 2021
• Est. primary completion date: September 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

• Over 18 years old
• Hospitalization in the Department of Emergency Psychiatry and Acute Care (Montpellier University Hospital) between 2012 and 2019
• Having being enrolled in one the department's clinical studies between 2012 and 2019
• Moderate to severe characterized depressive episode according to DSM-5 diagnostic criteria (severity assessed with BDI, IDSC-30 and QIDS)

Exclusion criteria:

• Protection by law (guardianship or curatorship)
• Deprivation of liberty (by judicial or administrative decision)
• Bipolar disorder

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Locations

Country	Name	City	State
France	Uhmontpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	characterization of the patient clinical phenotype	characterization of the patient clinical phenotype	day 1
Secondary	Suicidal events at one year	Occurrence of suicidal events (actual, interrupted and aborted or self-aborted suicide attempts) assessed with C-SSRS suicidal behaviour subscale (4 yes/no questions)	1 year
Secondary	Hospitalization for suicidal ideation	Occurrence of hospitalization for suicidal ideation, based on the patient medical record	1 year
Secondary	Suicidal events at one year	Occurrence of suicidal events (actual, interrupted and aborted or self-aborted suicide attempts) based on the patient medical records	1 year