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Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination — CNF-rumination  

Depression Clinical Trial

Official title:
Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination

Clinical Trial Summary

The purpose of this study is to assess the feasibility and efficacy of real-time fMRI neurofeedback for rumination.

Clinical Trial Description

Neuroimaging MRI techniques for measuring brain structure, tissue composition, and Blood Oxygenation Level Dependent functional Magnetic Resonance imaging (BOLD fMRI) will be used to measure task-dependent and task-independent brain hemodynamic and electrophysiological changes in human subjects with major depressive disorders (MDD). After being informed about the study and potential risks, all participants giving written informed consent will undergo one session of the cognitive process-based fMRI neurofeedback (CNF) targeting the rumination-related brain functional connectivity, and a one-week follow-up. Participants will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to Active (receiving feedback from their own brain activity) or Sham (receiving artificially generated feedback). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04941066
Study type Interventional
Source Laureate Institute for Brain Research, Inc.
Contact
Status Completed
Phase N/A
Start date March 1, 2021
Completion date March 31, 2022
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