Transdiagnostic Cognitive Biomarkers

Status Recruiting

Clinical Trial Summary

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Clinical Trial Description

This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited. Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04864080
Study type	Interventional
Source	University of Minnesota
Contact	David Darrow
Phone	(612) 624-6666
Email	hdlab@umn.edu
Status	Recruiting
Phase	N/A
Start date	April 11, 2022
Completion date	March 1, 2026

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