Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT04738084 |
Other study ID # |
#20-MERU-107 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
August 21, 2020 |
Est. completion date |
December 30, 2021 |
Study information
Verified date |
July 2023 |
Source |
Meru Health, Inc. |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
This is a randomized controlled trial (RCT) of the Meru Health Program (MHP) versus a
waitlist (WL) control group, which will be offered access to the MHP after the waitlist
period (12 weeks) is over, for adults with depression. The Meru Health Program (MHP) is a
12-week mobile mental health intervention delivered via Smartphone app that includes
components of several evidence-based treatments (Cognitive Behavioral Therapy, Behavioral
Activation Therapy, Mindfulness Meditation) and also several promising therapies (heart rate
variability-biofeedback [HRVB], nutritional psychiatry, sleep training) that is overseen by a
licensed clinical therapist.
Description:
Title: Randomized Controlled Trial of the Meru Health Program versus Waitlist Control for
Adults with Depression
Study Description: This is a randomized controlled trial (RCT) of the Meru Health Program
(MHP) versus a waitlist (WL) control group, which will be offered access to the MHP after the
waitlist period (12 weeks) is over, for adults with depression.
Objectives*:
Primary Objective: To compare changes in depressive symptoms and reduction in clinically
significant depression at the end of the program and compare between those in the MHP group
versus WL group
Secondary Objectives: To compare changes in anxiety, worker productivity, burnout symptoms,
resilience, insomnia, quality of life, days spent engaging with the program per week and
hours spent in various program activities per week between those in the MHP group versus WL
group
Endpoints*:
Primary Endpoint: Depressive symptoms and adverse events at 12 weeks
Secondary Endpoints: Anxiety, worker productivity, burnout, resilience, insomnia, and quality
of life at 12 weeks; days spent engaging with program per week and hours spent in various
program activities per week, program satisfaction, therapist rating, system usability scale..
Study Population: Patients aged 18 or older presenting to the Meru Health Program with
depression (defined as having a PHQ-9 score of 10 or higher at baseline)
Description of Sites/Facilities Enrolling Participants: MHP online clinic
Description of Study Intervention/Experimental Manipulation: The Meru Health Program (MHP) is
a 12-week mobile health app delivered via Smartphone that includes components of several
evidence-based treatments (Cognitive Behavioral Therapy, Behavioral Activation Therapy,
Mindfulness Meditation) and also several promising therapies (heart rate
variability-biofeedback [HRVB], nutritional psychiatry, sleep training) that is overseen by a
licensed clinical therapist. This study will test the MHP versus a WL control group, of which
patients enrolled will be offered access to the MHP after 12 weeks in the WL control group,
to compare groups on depressive symptom outcomes and, secondarily, on other mood and
behavioral outcomes, engagement, and patient satisfaction outcomes.
Study Duration*: 1 year
Participant Duration: 12 weeks