Adolescent Depression Associated With Parental Depression

Depression Clinical Trial

— AdoDesP  

Official title:

Adolescent Depression Associated With Parental Depression : Screening, Prevalence and Secondary Prevention From the Meeting of Depressed Parents on Primary Care

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03811041
• Other study ID #: 29BRC18.0221
• Status: Terminated
• Phase: N/A
• Start date: March 28, 2019
• Est. completion date: March 11, 2021

Study information

• Verified date: April 2022
• Source: University Hospital, Brest
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Depression is difficult to identify, prevent and treat in adolescents because of complex and stigmatized multiform symptoms and pathways of care.

In children the existence of a parental depression is a significant and recognized risk factor for the development of a depression. It is regularly reported that 30% of adolescents of depressed parents have depression themselves. General Practitioners (GP) have significant access to the depression of adults, potentially parents of teenagers. In fact, 20% of patients in the regular active file of one GP have depression. The primary health care system could provide indirect but voluminous and unprecedented access to the identification of adolescent depression at an early stage from the encounter of depressed parents.

The difficulties of articulation between primary care (PC) and mental health devices are demonstrated. They disrupt the care pathways of adolescents detected in PC, prevention, and may even disturb early detection of depression. An organized joint between the PC and a specialized mental health service for adolescents ("Maison Des Adolescents" MDA) could promote the process of screening and preventing depression of adolescents of depressed parents encountered in PC.

In addition, if the effects of parental depression on adolescents are established, they remain complex and interactive. They vary by age and sex of the child but also the sex of the parent. A concomitant study of adolescent and parent depression will provide data to analyze the prevalence of depressed parent adolescent depression and to define risk or protection factors.

AdoDesP study is a cluster randomised trial (randomisation of the GPs) which compare a group of adolescent with PC articulated with mental health service (MDA) and an other group without articulation (routine cares).

A third group of depressed adolescents will be constituted to analyse parental depression of depressed adolescents.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 80
• Est. completion date: March 11, 2021
• Est. primary completion date: March 11, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 11 Years and older

Eligibility

Inclusion Criteria:

• Parents of groups 1 and 2 :

• Major patient consulting his GP

• Depressed patient

• Parent of adolescent aged between 11 and 18 years old

• Adolescents of groups 1 and 2 :

• Aged more than 11 and less than 18 years old

• Parent included in the study

• Parents of group 3 :

• Parent of depressed adolescent under care at the MDA of Marseille, included in the study and whose depression is confirmed by HSCL25 scale

• Adolescents of group 3 :

• Aged more than 11 and less than 18 years old

• Depressed patient

• Under care at the MDA of Marseille since less than 1 month

Exclusion Criteria:

• Parents of groups 1, 2 and 3 :

• Minor patient

• Enable to give his consent

• Patient with guardianship or curatorship

• Non consenting patient

• Pregnant or nursing mother

• Adolescents of groups 1 and 2 :

• Aged < 11 or =18

• Parent whose depression isn't confirmed by HSCL25 scale

• Non consenting adolescent

• Pregnant or nursing mother

• Adolescent of group 3 :

• Aged < 11 or =18

• Non depressed adolescent

• Non consenting patient

• Pregnant or nursing mother

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Intervention

Other:
• MDA
Depressed adolescents of depressed parents will be oriented to the MDA of Brest for depression cares.
• Routine Cares
Depressed adolescents of depressed parents will be oriented to routine cares for depression cares.
• Parental depression
Parents of depressed adolescents will be met for a screening test of depression.

Locations

Country	Name	City	State
France	Dr Phan	Brest
France	Dr Volant-Le-Berre	Brest
France	Dr Wauters	Brest
France	Dr AUGUSTIN	Guilers
France	Dr Le Grignou	Guissény
France	Dr Ac'h	Landerneau
France	Dr PITMAN	Landivisiau
France	Dr CHIRON	Le Relecq-Kerhuon
France	Dr CONNAN	Le Relecq-Kerhuon
France	Dr Cazuguel	Locmaria-Plouzané
France	Dr Coat-Gourio	Plougastel-Daoulas
France	Dr NABBE	Plounéour-Trez

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Brest

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in adolescents' depression intensity	The depression intensity will be evaluated by Adolescent Depression Rating Scale (ADRS) at Day 0 and Month 12. The investigators will compare its evolution between group 1 (PC articulated with MDA) and 2 (Routine cares).; Adolescent depression rating scale (ADRS) assesses depression in adolescents in 10 items. The items measure insomnia, anxiety, sadness and fatigability. If ADRS score is less than 4 : low risk of depression, between 4 and 8 : moderate risk of depression and more than 8 : significant risk of depression.	Day 0 and Month12
Secondary	Diagnosis of depression rate	With group 1 and 2, screening rates for depression in adolescents will be evaluated at Day 0	Day 0
Secondary	Changes in adolescents' quality of live	The quality of live will be evaluated by Pediatric Quality of Life InventoryTM (PedsQL) scale at Day 0, Months 6 and 12 and the investigators will compare its evolution between group 1 and 2. 3 scores will be calculated : psychosocial health summary score (average score of 15 items), physical health summary score (average score of 8 items) and the total score (average score of all items). Scores are between 0 and 100% and the higher scores indicate better Health-Related Quality of Life.	Day 0, Month6 and Month12
Secondary	Prevalence of adolescent depression with depressed parent	With group 1 and 2, the investigators will calculate de prevalence of adolescent depression when a parent is depressed. Adolescent depression will be assessed by Adolescent Depression Rating Scale (ADRS). This scale is composed of 8 true (1)/false(0) questions. The score is the sum of all item. An adolescent is consider depressed when his score is higher than 4.	Day 0
Secondary	Prevalence of parental depression with depressed adolescent	With group 3, the investigators will calculate de prevalence of parental depression when a adolescent is depressed. Parental depression will be assessed by Hopkins Symptom Checklist (HSCL25). This scale is composed of 25 questions with 4 answers (1-4). The score is the average score of the 25 items. The parent is considered depressed when the score is higher or equal to 1.75.	Day 0
Secondary	Risk and protection factors	With the 3 groups, the investigators will isolate risk and protection factors for adolescent of depressed parents and for parents of depressed adolescents. Sociodemographics informations will be used and protective or risk factors may be highlighted from the study of some of the medico-psychological and social characteristics of families.	Day 0