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Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease — KETAPAL  

Depression Clinical Trial

Official title:
Evaluation of the Initial Prescription of Ketamine and Milnacipran Forin Depression in Patients With a Progressive Disease

Clinical Trial Summary

KetaPal is a placebo-controlled randomized trial designed to demonstrate the antidepressant action of ketamine in palliative care situations. Half of participants will receive Ketamine and Milnacipran in combination, while the other half will receive a Placebo and Milnacipran in combination.

Clinical Trial Description

Ketamine, a molecule mainly used as an analgesic in palliative care, turns out to be an excellent fast acting antidepressant. By acting as an NMDA receptor antagonist, its mechanism of action is complementary to classical and long acting antidepressants like Selective Serotonin Reuptake Inhibitors (SSRI). In particular, ketamine is able to boost synaptogenesis in only a few hours whereas long-term prescription of SSRI can stimulate neurogenesis. The purpose of this study is to evaluate a new therapeutic strategy that could integrate ketamine in the same time than SSRI, to control depression symptoms faster and optimize patient's quality of life complementary to treatments of cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02783430
Study type Interventional
Source University Hospital, Lille
Contact Antoine LEMAIRE, MD
Email lemaire-a@ch-valenciennes.fr
Status Recruiting
Phase Phase 2/Phase 3
Start date September 8, 2016
Completion date September 2024
View Details
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