Depression Clinical Trial
Official title:
Phototherapy in Young People With Depression; Investigating Associations Between Changes in Actigraphic Sleep-wake Profile and Depressive Symptoms
Bright light therapy is an established treatment pathway for sleep and circadian disorders
and evidence suggests that it has antidepressant effects. The underlying mechanisms of these
antidepressant effects are not fully understood and results from previous studies are
somewhat variable. One of the important limitations of previous depression studies has been
the heterogeneity of samples in which bright light therapy has been administered.
The main aim of this study is to evaluate whether the antidepressant effects of phototherapy
in young persons with depression are modulated by changes in the sleep-wake cycle. We
hypothesize that more pronounce initial sleep-phase delay will predict better antidepressant
response to phototherapy and that the magnitude of changes in depressive symptoms across the
course of the intervention will correlate with changes in the sleep-wake cycle.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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