Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression.

Depression Clinical Trial

Official title: A Randomized Double-Blind Placebo-Controlled Pilot Study of L-tyrosine and L-tryptophan in Depressed Patients Receiving L-methylfolate and and SSRI

Status Withdrawn

Clinical Trial Summary

**This study never received IRB approval and no participants were ever enrolled** The purpose of this study is to determine if adding over the counter nutritional supplements will have a benefit to participants currently taking prescribed antidepressants who have not experienced complete remission of their depression symptoms.

Clinical Trial Description

Inclusion Criteria:

Detroit VA Patients with major depression, mild to moderate treated with an SSRI and not having complete remission of symptoms as defined by "feeling their normal selves"

Randomized into two groups:

Experimental: will receive month supply of deplin 15mg, L-tyrosine 6g/d into 2 divided doses, and L-tryptophan 2g/d into 2 divided doses.

Control: will receive month supply of deplin 15mg , and 2 placebo pills.

Beck Depression Scale (BDI-2) to be administered at baseline and every 2 weeks for 1 month. ;

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

• NCT number: NCT02223299
• Study type: Interventional
• Source: John D. Dingell VA Medical Center
• Status: Withdrawn
• Phase: N/A
• Start date: November 2015
• Completion date: November 2015