Mindfulness Intervention to Study the Neurobiology of Depression

Depression Clinical Trial

— MIND  

Official title:

Mindfulness Intervention to Study the Neurobiology of Depression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01905267
• Other study ID #: 2012-0689
• Status: Completed
• Phase: N/A
• Start date: March 2013
• Est. completion date: June 2017

Study information

• Verified date: October 2017
• Source: University of Illinois at Chicago
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The Pediatric Mood Disorders Program at the University of Illinois at Chicago is conducting a research study examining how mindfulness can help teenagers stay healthy and prevent depression relapse.

Description:

Study involves:

• Brain scan using fMRI technology

• Questions about mood and behavior

• Meeting with a clinician

• Possibility of 8 weekly treatment sessions using mindfulness

• Ongoing assessment of depression for next 2 years

Eligible participants will be compensated for their time.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: June 2017
• Est. primary completion date: June 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Years to 18 Years

Eligibility

Inclusion Criteria:

• between the ages of 12 and 18

• history of major depressive disorder

Exclusion Criteria:

• braces

• afraid of small spaces

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Intervention

Behavioral:
• Rumination-Focused Cognitive Behavior Therapy
This intervention targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effective coping strategies. Mindfulness is a key component of this intervention as a strategy for disengaging from one's thoughts. Strategies from Dialectical Behavior Therapy (DBT), such as the use of effective interpersonal skills, are also included as methods for regulating strong emotion. Rumination-Focused Cognitive Behavior Therapy is a structured, manual based program designed to be delivered weekly over eight weeks. Sessions are 60-90 minutes in length.

Locations

Country	Name	City	State
United States	University of Illinois at Chicago Pediatric Mood Disorders Program	Chicago	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
University of Illinois at Chicago

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Children's Depression Rating Scale - Revised	clinician measure completed with adolescent and parent Total scores reported. Range is between 17-119 Higher scores mean higher depressive symptoms	Baseline, 8 week
Secondary	Change in Reynolds Adolescent Depression Scale	Self report adolescent depression total score. Range is 30-120 with higher scores meaning greater depressive symptoms.	Baseline, 8 week