Short-term Cognitive Training in Late-life Depression

Depression Clinical Trial

Official title:

The Effects of Short-term Cognitive Training on Cognition and Mood Symptoms in Late-life Depression: A Pilot Study

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01748032
• Other study ID #: 12-28
• Status: Terminated
• Phase: N/A
• First received: December 10, 2012
• Last updated: April 6, 2016
• Start date: August 2012
• Est. completion date: September 2014

Study information

• Verified date: April 2016
• Source: Rotman Research Institute at Baycrest
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD).

The hypotheses are:

1. post-training cognitive performance will be superior to pre-training cognitive performance

2. post-training depressive symptomatology will be less severe as compared with pre-training clinical severity and

3. AUT group will show better post-training cognitive performance and improved mood symptoms when compared with the WAT group.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 6
• Est. completion date: September 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Male or female

• Age >=55

• Proficiency in English

• Current depressive episode and meet criteria for DSM-IV major depressive disorder

• Hamilton Depression Rating Scale score >=15

• Able to give informed consent

• Stable medication dosages during the training period

Exclusion Criteria:

• Other DSM-IV Axis I psychiatric disorders, except for anxiety disorders due to high comorbidity with mood disorders

• Mini-Mental State Examination score of <26

• Diagnosis of dementia

• Neurological and medical conditions known to affect cognition (e.g., stroke, head injury, previous chemotherapy for cancer)

• Unstable medical illnesses requiring active treatment

• Vision or hearing impairment affecting ability to participate in training

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Intervention

Behavioral:
• Cognitive training
20 minutes/day for 5 sequential working days

Locations

Country	Name	City	State
Canada	Rotman Research Institute at Baycrest	Toronto	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
Rotman Research Institute at Baycrest	Baycrest

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed	Computerized Executive Tasks: Number-Letter Task; Letter-Memory Task; Stroop Task; Non-Computerized Measures: Cattell Culture Fair Intelligence Test; Mattis Dementia Rating Scale-2 (DRS-2)	Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day	No
Secondary	Changes in mood including depression, anxiety and apathy	Montgomery Asberg Depression Rating Scale (MADRS); Apathy Evaluation Scale (AES); Hamilton Anxiety Rating Scale (Ham-A); Beck Depression Inventory (BDI)	Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day	No