Depression Clinical Trial
Official title:
A Randomised Trial on the Usefulness of Supportive Text Messages in the Treatment of Depressed Patients With Co-morbid Alcohol Dependency Syndrome
Background:
There is abundant evidence that rates of comorbidity between substance use and depression
are high (1, 2) and the risk of poor outcome is higher among individuals with the dual
disorder compared with those with a single disorder (3, 4, 5, 6). Previous research has
shown that about 50% of persons studied with severe mental illness and past substance abuse
are likely to have a recurrence of substance abuse within 1 year of discharge from treatment
(7).
There is therefore a clear clinical challenge in treating patients with the dual disorder
which may calls for further research and the possible introduction of new and innovative
strategies including the use of mobile phone technology to provide increased support for
patients with the dual diagnosis.
There are established research evidence for using Short Message Service (SMS) text messages
to remind patients of scheduled medical appointments (8,9,10,12, 13), coordinate medical
staff,(14) deliver medical test results,(15,16) , promote smoking cessation ( 17), improve
self-monitoring among the youth with type 1 diabetes( 18), promote weight loss among obese
subjects (19 ) and monitor patient side effects following treatment(20).
Relevance of the research:
To date, after an extensive review of the literature using MEDLINE, Pub Med, ERIC, Web of
Science, Science Direct and PsycINFO, no studies was found on the use of SMS text messages
as an intervention to address abstinence amongst alcohol dependent subjects who are
co-morbid for a depressive disorder. Thus, the investigators seek to determine if text
messaging is a useful and effective strategy to help maintain abstinence, improve adherence
with medication and ultimately promote mental stability in depressed patients discharged
from an in-patient dual diagnosis programme. The investigators hypothesize that, daily
supportive/reminder SMS text messages to depressed patients discharged from an in-patient
dual diagnosis programme would increase alcohol abstinence rates , improve medication
adherence rates and improve the overall mental well being of patients compared with those
receiving treatment as usual.
There is abundant evidence that rates of comorbidity between substance use and depression
are high (1, 2). The risk of poor outcome is higher among individuals with both substance
use and mood disorders compared with those that have a single disorder (3, 4, 5, 6).
Previous research has shown that about 50% of persons studied with severe mental illness and
past substance abuse are likely to have a recurrence of substance abuse within 1 year of
discharge from treatment (7). In a study to evaluate the effectiveness of the dual diagnosis
treatment programme established in St Patricks' Hospital in Dublin, it was discovered that
71.8% of patients achieved complete abstinence at 3 months and 55.8% at 6 months in the
depression group(8).
There is therefore a clear clinical challenge in treating patients with the dual disorder
which calls for further research and the introduction of new and innovative strategies
capable of improving upon abstinence rates among patients. Such strategies could include the
use of mobile phone technology to provide increased support for patients with the dual
diagnosis which may translate into increase abstinence rates over time.
Significantly, mobile telephones are becoming integrated into virtually all aspects of
society,(9,10,1112) and may provide an opportunity to improve health related behaviours , in
particular through the use of Short Message Service (SMS) (13 ). In a randomized controlled
trial to evaluate a text message-based intervention designed to help individuals lose or
maintain weight over 4 months, the intervention group who received personalized SMS and MMS
messages sent two to five times daily, printed materials, and brief monthly phone calls from
a health counsellor lost more weight than the comparison group who only received only
monthly printed materials (14). In another study, sending text messages to mobile phones
increased the effectiveness of a smoking cessation intervention among college students (15).
Similarly, in a program conducted among youth with type 1 diabetes (16), daily text messages
were helpful for disease self-management, increased self-efficacy, and treatment adherence
and achieved high satisfaction among participants. Again, weekly SMS self-monitoring of
bulimic symptoms with automatic SMS feedback resulted in good monitoring adherence and
acceptability in women aged 16 to 44 post-discharge from inpatient treatment (17). There are
also established research evidence for using SMS to remind patients of scheduled medical
appointments,(18,19,20,21, 22) coordinate medical staff,(23) deliver medical test
results,(24,25,26) and monitor patient side effects following treatment(27).
To date, after an extensive review of the literature using MEDLINE, Pub Med, ERIC, Web of
Science, Science Direct and PsycINFO, no studies was found on the use of daily text messages
delivered via mobile phone as an intervention to address abstinence amongst alcohol
dependent subjects who are co-morbid for a depressive disorder. Thus, we seek to determine
if text messaging is a useful and effective strategy to help maintain abstinence, improve
adherence with medication and ultimately promote mental stability in depressed patients
discharged from an in-patient dual diagnosis programme. We hypothesize that, daily
supportive/reminder SMS text messages to depressed patients discharged from an in-patient
dual diagnosis programme would increase alcohol abstinence rates , improve medication
adherence rates and improve the overall mental well being of patients compared with those
receiving treatment as usual. Patients receiving the text messages and phone calls would
also report a favourable experience and an overall satisfaction with the system.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05777044 -
The Effect of Hatha Yoga on Mental Health
|
N/A | |
Recruiting |
NCT04977232 -
Adjunctive Game Intervention for Anhedonia in MDD Patients
|
N/A | |
Recruiting |
NCT04680611 -
Severe Asthma, MepolizumaB and Affect: SAMBA Study
|
||
Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
Completed |
NCT04512768 -
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
|
N/A | |
Recruiting |
NCT03207828 -
Testing Interventions for Patients With Fibromyalgia and Depression
|
N/A | |
Completed |
NCT04617015 -
Defining and Treating Depression-related Asthma
|
Early Phase 1 | |
Recruiting |
NCT06011681 -
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
|
||
Completed |
NCT04476446 -
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
|
Phase 3 | |
Recruiting |
NCT02783430 -
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
|
Phase 2/Phase 3 | |
Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
Completed |
NCT04598165 -
Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal Support
|
N/A | |
Completed |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
||
Recruiting |
NCT05956912 -
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
|
||
Completed |
NCT05588622 -
Meru Health Program for Cancer Patients With Depression and Anxiety
|
N/A | |
Recruiting |
NCT05234476 -
Behavioral Activation Plus Savoring for University Students
|
N/A | |
Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
Enrolling by invitation |
NCT03276585 -
Night in Japan Home Sleep Monitoring Study
|
||
Terminated |
NCT03275571 -
HIV, Computerized Depression Therapy & Cognition
|
N/A | |
Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A |