Depression Clinical Trial
— MBSRforPTSDOfficial title:
Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study
PTSD is a common consequence of war, for soldiers and civilians. PTSD results in
hyperarousal, avoidance, numbing, and re-experiencing, causing persistent decreased quality
of life. Mindfulness involves the ability to bring attention to the present moment without
judgment; this ability is correlated with measures of mental health. Within health care,
mindfulness is taught as an 8-week course called Mindfulness-Based Stress Reduction (MBSR).
MBSR is unstudied for PTSD. We propose to assess the feasibility of MBSR as an intervention
for PTSD, since it may affect hypervigilance, avoidance, and reactivity associated with this
disorder.
Specific Aims: Aim 1: Assess the feasibility of recruiting and retaining a sample of
veterans with PTSD to complete a study protocol that involves randomization to usual care or
usual care plus MBSR. Aim 2: Apply measures of PTSD symptom severity, depression and quality
of life before and after randomization, to assess whether there is evidence of benefit and
whether MBSR warrants further study for PTSD, and allow calculation of standardized effect
sizes. Aim 3: Apply a validated measure of mindfulness before and after treatment. Aim 4:
Explore the relationship between PTSD symptoms, mindfulness score, and frequency of
meditation practice.
Status | Completed |
Enrollment | 50 |
Est. completion date | December 2009 |
Est. primary completion date | December 2009 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Must have PTSD Exclusion Criteria: - Active substance use - Active suicidal ideations - Borderline or antisocial personality disorder |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | VA Puget Sound Health Care System | Seattle | Washington |
Lead Sponsor | Collaborator |
---|---|
Seattle Institute for Biomedical and Clinical Research | Puget Sound Partners for Global Health |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | PTSD symptom score | baseline, after MBSR and 4 months later | Yes | |
Secondary | depression (PHQ9) | baseline, after MBSR and 4 months later | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05777044 -
The Effect of Hatha Yoga on Mental Health
|
N/A | |
Recruiting |
NCT04977232 -
Adjunctive Game Intervention for Anhedonia in MDD Patients
|
N/A | |
Recruiting |
NCT04680611 -
Severe Asthma, MepolizumaB and Affect: SAMBA Study
|
||
Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
Completed |
NCT04512768 -
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
|
N/A | |
Recruiting |
NCT03207828 -
Testing Interventions for Patients With Fibromyalgia and Depression
|
N/A | |
Completed |
NCT04617015 -
Defining and Treating Depression-related Asthma
|
Early Phase 1 | |
Recruiting |
NCT06011681 -
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
|
||
Completed |
NCT04476446 -
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
|
Phase 3 | |
Recruiting |
NCT02783430 -
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
|
Phase 2/Phase 3 | |
Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
Completed |
NCT04598165 -
Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal Support
|
N/A | |
Completed |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
||
Recruiting |
NCT05956912 -
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
|
||
Completed |
NCT05588622 -
Meru Health Program for Cancer Patients With Depression and Anxiety
|
N/A | |
Recruiting |
NCT05234476 -
Behavioral Activation Plus Savoring for University Students
|
N/A | |
Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
Enrolling by invitation |
NCT03276585 -
Night in Japan Home Sleep Monitoring Study
|
||
Terminated |
NCT03275571 -
HIV, Computerized Depression Therapy & Cognition
|
N/A | |
Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A |