Depression Clinical Trial
Official title:
Cognitive Behavioral Adherence Intervention for Depressed HIV Patients
This study will compare the effectiveness of a cognitive behavioral intervention versus usual clinic care in helping HIV infected adults with depression to take their HIV medications on schedule.
Antiretroviral therapy (ART) is a type of medication treatment for HIV that impairs the
virus's ability to multiply. When used properly, it has been shown to be successful in
reducing HIV-related deaths. A high adherence rate to ART is required to adequately suppress
the virus, limit drug resistance, and reduce transmission. HIV infected people who are
depressed often experience increased difficulty with adhering to their ART regimen. This
study will compare the effectiveness of a cognitive behavioral intervention that targets
both depression and adherence versus usual care practices which may or may not include
mental health intervention with the goal of improving ART adherence among HIV infected
adults with depression who are experiencing difficulty with adhering to their medication
regimen.
This study will last 24 weeks. Participants will be randomly assigned to receive the
cognitive behavioral intervention or usual care. Study visits for all participants will
occur at baseline and Weeks 4, 8, 16, and 24. Those receiving the intervention will also
have visits at Weeks 1 and 2. Participants receiving the intervention will attend five
individual treatment sessions followed by one to three booster treatment sessions; these
sessions will coincide with the study visits.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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