Depression Clinical Trial
Official title:
Fibromyalgia Family Study Registry
The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.
FMS predominantly affects women and is characterized by chronic widespread musculoskeletal
pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The
pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine
factors seem to be of major importance. Studies of familial association suggest that genetic
factors play a role in FMS. This study will establish patterns of genetic linkage in
families with FMS.
Participating family members will undergo a brief physical exam (including tender point
exam), donate a blood sample, and complete a detailed questionnaire that includes experience
with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations.
Measurements of serum serotonin and related compounds will also be obtained. To detect
genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be
performed.
;
Observational Model: Family-Based, Time Perspective: Retrospective
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