Depression Clinical Trial
Official title:
CBASP Augmentation for Treatment of Chronic Depression
This 24-week study, with a 12-month follow up period, will compare the effectiveness of antidepressant medication alone to the combination of psychotherapy and antidepressant medication in patients with chronic depression.
Chronic depression affects approximately 5% of adults in the United States and is associated
with significant functional impairment and high health care utilization. The combination of
drug treatment and psychotherapy may be most effective in treating depression. This study
will determine the effects of adjunctive psychotherapy in depressed patients who have failed
to respond or have responded only partially to an initial trial medication.
Participants receive an initial trial of antidepressant medication for 8 to 12 weeks.
Participants who continue to have depressive symptoms are randomly assigned to add Cognitive
Behavioral Analysis System of Psychotherapy (CBASP) or supportive therapy to their medication
regimens or to continue pharmacotherapy alone for an additional 12 weeks. Assessments are
made at 6 and 12 months post-treatment.
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