Treating Alcohol Use In Older Adults With Depression

Depression Clinical Trial

Official title:

The Treatment of Late Life Major Depression Complication by Alcohol

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00018824
• Other study ID #: MHBS-009-98S
• Status: Completed
• Phase: Phase 4
• First received: July 3, 2001
• Last updated: September 21, 2009
• Start date: October 1999
• Est. completion date: January 2005

Study information

• Verified date: September 2009
• Source: VA Office of Research and Development
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.

Description:

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 74
• Est. completion date: January 2005
• Est. primary completion date: January 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Age > 55

• Current depressive syndrome

• Current alcohol dependence

• No psychosis

• No opioid or cocaine abuse or dependence

Exclusion Criteria:

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Alcoholism
• Depression
• Depressive Disorder

Intervention

Drug:
• NALTREXONE

• Placebo

Locations

Country	Name	City	State
United States	University of Pennsylvania	Philadelphia	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States, 

References & Publications (1)

Oslin DW. Treatment of late-life depression complicated by alcohol dependence. Am J Geriatr Psychiatry. 2005 Jun;13(6):491-500. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Alcohol use`		12 weeks	No