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Clinical Trial Summary

First, the investigators examined the functional relevance of serotonin transporter polymorphisms by quantifying the activity of serotonin transporter in blood platelets of genotyped healthy volunteers and patients with major depression.

Second, the investigators studied response to SSRIs in relation to 5-HTTLPR genotype and also to the functional expression of 5-HTT in platelets.


Clinical Trial Description

The purpose of this study is

1. to determine whether serotonin transporter genotypic or functional differences between depressive patients and normal controls were existed.

2. to determine the relationship between serotonin transporter polymorphisms and serotonin transporter functional expression.

3. to determine whether genomic or functional differences between drug responders and nonresponders predict the response of antidepressant ;


Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01237275
Study type Interventional
Source Samsung Medical Center
Contact
Status Active, not recruiting
Phase N/A
Start date October 1999
Completion date December 2016

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