Mechanisms of Change of Positive Interventions in Reducing Vulnerability for Depression — MINDCOG  

Depression in Remission Clinical Trial

Official title: Understanding Mechanisms of Prevention of Depression: a Mechanistic Cross-over Trial of Mindfulness vs. Fantasizing to Reduce Perseverative Cognition Underlying Vulnerability for Depression

Status Recruiting

Clinical Trial Summary

The purpose of this study is to understand the effects of mindfulness and fantasizing in reducing perseverative cognition underlying vulnerability for depression.

Clinical Trial Description

A cross-over design will be used comparing measures before and during both a mindfulness- and a positive fantasizing intervention period in individuals who remitted from two major depressive episodes (i.e. remitted Major Depressive Disorder (rMDD) patients) and a never-depressed control group. After checking for eligibility of the participants, participants will fill-out several questionnaires about their personal characteristics, experiences and expectations. These questionnaires will be used to study individual characteristics that could serve as treatment markers predicting the effectivity of interventions. Furthermore, diary measures of thought patterns (experience sampling method [ESM]), behavioural measures (using the Sustained Attention to Response Task [SART]), actigraphy, (neuro)physiological measures (impedance cardiography [ICG], electrocardiography [ECG] and electroencephalogram [EEG]) and measures of depressive mood (self-report questionnaires) will be performed during the week before (pre-) the interventions and the week during (peri-) performance of the interventions. In-between pre-and peri-intervention measures, there is a one month wash-out period. The order of the interventions will be counterbalanced across participants. Pre- and peri-intervention measures will be compared to study intervention effects in remitted MDD patients, remitted MDD patients vs. healthy controls and in relation with individual characteristics ;

Related Conditions & MeSH terms

• Depression
• Depression in Remission
• Depressive Disorder

• NCT number: NCT06145984
• Study type: Interventional
• Source: University Medical Center Groningen
• Contact: Marie-José van Tol, professor
• Phone: +31503616405
• Email: m.j.van.tol@umcg.nl
• Status: Recruiting
• Phase: N/A
• Start date: June 19, 2020
• Completion date: January 1, 2024