Dementia Clinical Trial
Background
Cognitive impairment in Parkinson's disease (PD) is common, even in the early stage of this
disease.The cumulative prevalence of dementia associated with Parkinson's disease (PDD) is
as high as 80% in a recent 8-year prospective study. However, some kinds of cognitive
impairment are not apparent and the value of self-report cognitive decline became limited.
In other words, some cognitive impairment may be detected by cognitive tests rather than
self-report of the symptoms.The early intervention of the cognitive impairment may be
helpful for these patients. Neuropsychiatric symptoms(NPSs) are also common in PD and PDD
patients. The severity of NPSs contributes to reduced quality of life and distress for
caregivers. Previous studies showed some different clinical phenotypes of NPSs in PD or PDD
patients. Among the NPSs, hallucination was considered a critical factor of cognitive
dysfunction in PD and PDD patients. The co-occurrence of NPSs in PD and PDD patients has
limited evidence now.
Purpose
To establish the screening tools for early detecting the PD patient with cognitive
impairment; exam the diagnostic value of MoCA and other cognitive tests in PD with mild
cognitive impairment, possible PDD, and probable PDD; understand neuropsychiatric symptoms
(NPSs) in these different patient groups; exam the relationship between each NPS and each
domain of cognitive dysfunction.
Methods
In order to exam the cognitive dysfunction in PDD (attention, executive function,
visuo-spatial function, and memory), several tests are performed. A 32-item cognitive
decline questionnaire will be used to screen the cognitive impairment in subjects.
Mini-Mental state examination (MMSE) and Montreal cognitive assessment (MoCA)are used for
cognitive evaluation. The detail evaluation of each domain is specified asfollowing: (1)
Attention (WAIS-R digit span), (2) Memory (12-item word recall test),(3) Executive function
(category verbal fluency), (4) Visuospatial function (cube copying and clock drawing). The
motor symptoms severity of the PD will be evaluated by the Hoehn & Yahr stage and motor
portion of the Unified Parkinson's Disease Rating Scale (UPDRS). The neuropsychiatric
symptoms will be recorded by Neuropsychiatric Inventory Questionnaire (NPI-Q). The daily
living activity will beevaluated by modified Lawton's instrumental activities of daily
living scale (IADL)and pill questionnaire. Subjects also receive 15-item Geriatric
Depression Scale(GDS-S) to evaluate the mood status. The clinician's diagnosis of dementia
will be based on the diagnostic criteria of DSM-IV, which will be compared with the
PDDdiagnostic criteria proposed by MDS in 2007. The investigators will also try to develop a
PDDscreening questionnaire.
Expected results
Cognitive impairment and dementia of PD patients will be ascertained by the cognitive test
battery. The screening questionnaire will be established. The heterogeneity of NPSs in PD
and PDD will be evaluated. The PDD screening questionnaire will help the clinician to
diagnose the patients.
n/a
Observational Model: Case Control, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05686486 -
Gentle Gymnastics and Relationship Between Family Caregivers and Residents With Dementia in Nursing Homes
|
N/A | |
Terminated |
NCT05451693 -
Outreach-ER: A Dementia Care Intervention Program
|
||
Recruiting |
NCT05820919 -
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
|
N/A | |
Enrolling by invitation |
NCT06040294 -
Dementia and Disability Simulation for College Nursing Students' Senior Activity Facilitation Skills
|
N/A | |
Completed |
NCT05114187 -
An Internet-Based Education Program for Care Partners of People Living With Dementia
|
N/A | |
Recruiting |
NCT06322121 -
Vascular Aspects in Dementia: Part 2
|
||
Active, not recruiting |
NCT03676881 -
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
|
||
Completed |
NCT04426838 -
Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad
|
N/A | |
Recruiting |
NCT03462485 -
Pilot Study of the Effects of Playing Golf on People With Dementia
|
N/A | |
Active, not recruiting |
NCT03677284 -
Managing Time With Dementia: Effects of Time Assistive Products in People With Dementia
|
N/A | |
Completed |
NCT03849937 -
Changing Talk Online (CHATO) Study
|
N/A | |
Recruiting |
NCT06284213 -
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
|
||
Recruiting |
NCT05579236 -
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
|
||
Completed |
NCT05080777 -
Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems
|
N/A | |
Completed |
NCT04571697 -
A Study of Comparing Rates of Dementia and Alzheimer's Disease in Participants Initiating Methotrexate Versus Those Initiating Anti-tumor Necrosis Factor (TNF)-Alpha Therapy
|
||
Completed |
NCT03583879 -
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
|
N/A | |
Recruiting |
NCT06033066 -
Financial Incentives and Recruitment to the APT Webstudy
|
N/A | |
Active, not recruiting |
NCT05204940 -
Longitudinal Observational Biomarker Study
|
||
Recruiting |
NCT05684783 -
Dementia Champions in Homecare
|
||
Completed |
NCT03147222 -
Function Focused Care: Fracture Care at Home
|
N/A |