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Dementia clinical trials

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NCT ID: NCT02317250 Withdrawn - Clinical trials for Mild Cognitive Impairment

Molecular Cerebral Imaging in Incipient Dementia (MCI-ID) II

Start date: June 2018
Phase: Phase 3
Study type: Interventional

A substantial portion of people covered by Medicare will develop Alzheimer's disease and other forms of dementia that together devastate the lives of millions of people in the United States, and cost us a total of over $200 billion every year. Getting a brain scan with a PET scanner to look for abnormal brain metabolism patterns is recognized as "reasonable and necessary" for some patients with "a recently established diagnosis of dementia" (Centers for Medicare and Medicaid Services (CMS), Decision Memo CAG-00088R), but the evidence is considered less clear for patients having less severe cognitive problems, and/or for patients getting a brain scan with a PET scanner to look for abnormal proteins in the brain (CMS Decision Memo CAG-00431N). This project employs a scientifically rigorous design (prospective, multi-centered, randomized controlled trial) to determine whether such PET scanning can help distinguish more accurately than is being done in current clinical practice those patients with early molecular changes in their brains who will benefit from Alzheimer related treatments from those patients who will not, as proven by measuring to what extent the PET scans actually lead to earlier appropriate therapy, and in fact result in improved outcomes for Medicare beneficiaries and for the health care system in which they obtain care.

NCT ID: NCT02246075 Withdrawn - Dementia Clinical Trials

Study of the Safety of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease Currently Receiving Memantine

Start date: July 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety of 2 fixed doses of EVP-6124 hydrochloride (HCl) compared to placebo for 24 weeks in subjects with mild to moderate Alzheimer's disease who are concurrently receiving stable treatment with memantine and currently receiving stable treatment or previously treated with an acetylcholinesterase inhibitor.

NCT ID: NCT01891383 Withdrawn - Dementia Clinical Trials

Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel

Start date: July 2013
Phase:
Study type: Observational

The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home, Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare the characteristics of dementia in those who have had a prior TBI to the characteristics in those without a history of TBI. It is our hypothesis that the dementia or MCI among those with prior TBI has distinct neuropsychological features that distinguishes it from those with dementia or MCI without a history of TBI.

NCT ID: NCT01887899 Withdrawn - Clinical trials for Dementia of Type Alzheimer

Influence of tDCS on Cortical Plasticity in Patients With Dementia of the Alzheimer Type

Start date: May 2013
Phase: N/A
Study type: Interventional

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with dementia of the Alzheimer type (DAT) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

NCT ID: NCT01256905 Withdrawn - Parkinsons Disease Clinical Trials

Attention Modulation for Treatment of Parkinson's Disease and Dementia With Lewy Bodies

Armodafinil
Start date: January 1, 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate if a drug commonly used to treat excessive day-time sleepiness, called armodafinil (Nuvigil), is also effective in improving the impairment in the attention commonly reported by patients with more advanced Parkinson's disease (PD) and Lewy body disease (LBD).

NCT ID: NCT01217268 Withdrawn - Dementia Clinical Trials

Use of Telemedicine in Collaboration Between a Psychogeriatric Unit and Nursing Homes

TESAM
Start date: October 2010
Phase: N/A
Study type: Interventional

The investigators want to evaluate the use of video-conference in the collaboration between the investigators psychogeriatric department and nursing homes. The study aim is to give supervision on a regular basis to the caregivers on a special care unit for patients with dementia with behavioural disturbances during a period of half a year. The investigators want to investigate the impact on caregivers and patients by applying certain tests at baseline, during the intervention and half a year after the intervention.

NCT ID: NCT01066481 Withdrawn - Dementia Clinical Trials

A Study Of Oral PF-01913539 In Patients With Mild To Moderate Alzheimer's Disease

Start date: April 2010
Phase: Phase 2
Study type: Interventional

The purpose of this study is to demonstrate the safety and efficacy of PF-01913539 in the treatment of patients with mild-to-moderate Alzheimer's Disease. It is a 6-month study enrolling 651 patients in Japan, Hong Kong, Korea, and Republic of China. All patients completing the 6-month study will be eligible to receive PF-01913539 in an open-label extension trial (B1451031).

NCT ID: NCT00907595 Withdrawn - Parkinson's Disease Clinical Trials

Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon

Start date: May 2009
Phase: N/A
Study type: Interventional

The proposed study is a double-blind, placebo controlled pilot study of HD, PD, and DLB subjects with sleep disturbances. This study is designed to determine the effects of 4 weeks Ramelteon treatment on the sleep patterns of people with basal ganglia disorders such as HD, PD and DLB. The study also aims to look at the sleep patterns of caregivers of people with HD, PD and DLB.

NCT ID: NCT00792662 Withdrawn - Diabetes Mellitus Clinical Trials

Improving Function, Quality of Life, Glycemia in Diabetics With Dementia

Start date: November 18, 2008
Phase: Phase 4
Study type: Interventional

The primary purpose of this study is to determine if the study medication Methylphenidate (Ritalin) will improve subject's blood-sugar control by improving their motivation more than placebo. The secondary objectives of the study are to determine if daily functioning and quality of life improves with methylphenidate treatment.

NCT ID: NCT00375557 Withdrawn - Dementia Clinical Trials

Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients

Start date: October 2006
Phase: Phase 4
Study type: Interventional

The primary aim is to determine whether Divalproex ER or one of the atypical antipsychotics is more effective improving dementia related behavioral symptoms in patients with dementia, and evaluate the impact of such improvements on other clinical domains, such as quality of life, functional status.