Degenerative Arthritis Clinical Trial
Official title:
A Placebo Controlled, Double-blind, Randomized, Parallel-group, Multi-center Phase III Study to Determine the Efficacy and Safety of TissueGene-C in Patients With Degenerative Arthritis
The purpose of this study is to determine whether TissueGene-C, an allogeneic human chondrocytes expressing Transforming Growth Factor(TGF)-b1, is effective and safe in patients with degenerative arthritis.
TissueGene-C is a biological new drug which consists of normal chondrocyte cells and
transduced chondrocyte cells that express growth factor to modify osteoarthritis symptom for
long term period.
During the Phase 3 clinical trial , we will compare TissueGene-C to placebo in 26, 52 weeks
trial with 156 outpatients who have osteoarthritis. The outpatients are randomized to
TissueGene-C or placebo in 1:1 ratio, and they will be monitored and recorded in terms of
alleviating symptoms, sports activities, function of the knee, and the presence of adverse
events.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT02820766 -
Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting
|
N/A | |
Withdrawn |
NCT01308515 -
Vanguard Knee Anterior Stabilized Versus Posterior Stabilized Bearing Study
|
N/A | |
Terminated |
NCT03247023 -
Long Term Follow-up of Integra® Cadenceâ„¢ Total Ankle System in Primary Ankle Joint Replacement
|
||
Terminated |
NCT05357664 -
PINNACLE® DM RSA Study
|
N/A | |
Completed |
NCT01825811 -
Efficacy and Safety Study of TissueGene-C Mixed With Fibrin-glue for the Patients With Degenerative Arthritis
|
Phase 2 | |
Terminated |
NCT01366989 -
INBONE Total Ankle Arthroplasty(TAA)Using Calcaneal Stem Fixation
|
N/A | |
Not yet recruiting |
NCT02286973 -
Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty
|
Phase 1 | |
Completed |
NCT01684371 -
The Effects of Elmore Oil on Patients With Osteoarthritis
|
N/A | |
Recruiting |
NCT00891501 -
The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects
|
Phase 2/Phase 3 | |
Completed |
NCT03000712 -
Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.
|
N/A | |
Withdrawn |
NCT04057885 -
To Determine the Gait and Functional Improvement in Total Knee Arthroplasty
|
N/A | |
Completed |
NCT04815070 -
Gastric Volume in Diabetic Patients Undergoing Staged Bilateral Total Knee Arthroplasty
|
||
Active, not recruiting |
NCT02038140 -
Zimmer Trabecular Metal Total Ankle PMCF
|
N/A | |
Recruiting |
NCT02469662 -
Clinical Outcomes Study of the Nexel Total Elbow
|
N/A | |
Terminated |
NCT00588887 -
Total Knee Replacement With Duracon® and Vanguardâ„¢ Prostheses
|
N/A | |
Completed |
NCT03990805 -
A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis
|
Phase 3 | |
Completed |
NCT02658344 -
Clinical Trial to Evaluate Efficacy and Safety of JOINTSTEM in Patients With Degenerative Arthritis
|
Phase 2 | |
Completed |
NCT01671072 -
Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis
|
Phase 2 | |
Not yet recruiting |
NCT04821102 -
Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration
|
N/A | |
Terminated |
NCT02405234 -
Ascension PyroCarbon Radial Head Study
|
N/A |