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Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis.

Cystic Fibrosis Clinical Trial

Official title:
Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis

Clinical Trial Summary

The goal of this clinical trial is to test use of losartan in those with cystic fibrosis (CF) on modulator therapy. The main question it aims to answer is if treatment with losartan improves response of the CF transmembrane conductance regulator (CFTR) channel to modulator therapy. Participants will be asked take losartan or placebo for twelve weeks and will have changes in sweat chloride levels measured as a marker of CFTR function.

Clinical Trial Description

This is a randomized, placebo-controlled, parallel group clinical trial in those those with CF on elexacaftor/tezacaftor/ivacaftor to determine if treatment with losartan improves response to modulator therapy using sweat chloride as an marker of CFTR function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06364176
Study type Interventional
Source University of Kansas Medical Center
Contact Heidi Hellwig
Phone 9135886045
Email hhellwig@kumc.edu
Status Recruiting
Phase Phase 2
Start date June 3, 2024
Completion date October 2027
View Details
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