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A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome

Cushing Syndrome Clinical Trial

Official title:
A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing's Syndrome (Cushing's Disease or Ectopic ACTH Syndrome)

Clinical Trial Summary

A Phase 1b/2a, first-in-disease, open-label, multiple-ascending dose exploratory study to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamic biomarker responses associated with CRN04894 (an adrenocorticotropic hormone [ACTH] receptor antagonist) in participants with ACTH-dependent Cushing's syndrome (Cushing's disease or Ectopic ACTH Syndrome [EAS])

Clinical Trial Description

This is a Phase 1b/2a, first-in-disease, open-label, multiple-ascending dose exploratory study to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamic biomarker responses associated with CRN04894 (an adrenocorticotropic hormone [ACTH] receptor antagonist) over a 10-day treatment period in participants with ACTH-dependent Cushing's syndrome (Cushing's disease or Ectopic ACTH Syndrome [EAS]).Participants will receive oral CRN04894 once daily for 10 days, followed by monitoring during 4 'wash-out' days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05804669
Study type Interventional
Source Crinetics Pharmaceuticals Inc.
Contact Crinetics Clinical Trials
Phone 833-827-9741
Email clinicaltrials@crinetics.com
Status Recruiting
Phase Phase 1/Phase 2
Start date October 12, 2023
Completion date October 2026
View Details
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