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Bicalutamide to Block TMPRSS2 in Males With COVID-19 Infection

COVID-19 Clinical Trial

Official title:
Randomized Trial of Bicalutamide to Block TMPRSS2 in Males With COVID-19 Infection

Clinical Trial Summary

COVID-19 outcomes are worse in male patients. Androgen signaling, therefore, is a target for clinical exploration. TMPRSS2 is a membrane protease required for COVID pathogenesis that is regulated by androgens. Blocking TMPRSS2 with bicalutamide may reduce viral replication and improve the clinical outcome. Therefore, the study proposes to test bicalutamide at 150 mg oral daily dosing in a double-blind placebo-controlled randomized trial in male patients with early symptomatic COVID-19 disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04509999
Study type Interventional
Source University of Florida
Contact
Status Withdrawn
Phase Phase 3
Start date October 26, 2020
Completion date June 30, 2021
View Details
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