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NCT ID: NCT06026553 Recruiting - Postoperative Pain Clinical Trials

Assessing Ketorolac (Toradol) at Oocyte Retrieval

Alleviate
Start date: August 10, 2022
Phase: Phase 1
Study type: Interventional

To determine if a nonsteroidal anti-inflammatory drug (NSAID), Ketorolac (Toradol), can improve pain control and decrease narcotic use after undergoing egg retrieval.

NCT ID: NCT06026514 Recruiting - Clinical trials for SARS-CoV-2 Infection

Phase I Safety Study of B/HPIV3/S-6P Vaccine Via Nasal Spray in Adults

Start date: September 18, 2023
Phase: Phase 1
Study type: Interventional

This Phase 1 clinical trial will evaluate the safety and immunogenicity of an intranasal vaccine candidate, a recombinant, live-attenuated, bovine/human parainfluenza virus vector vaccine expressing the 6-P prefusion-stabilized version of the SARS-CoV-2 spike protein.

NCT ID: NCT06026410 Recruiting - Clinical trials for Non Small Cell Lung Cancer (NSCLC)

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

FIT-001
Start date: October 18, 2023
Phase: Phase 1
Study type: Interventional

This first-in-human (FIH) dose-escalation and dose-validation/expansion study will assess KO-2806, a farnesyl transferase inhibitor (FTI), as a monotherapy and in combination, in adult patients with advanced solid tumors.

NCT ID: NCT06026397 Completed - Clinical trials for Chemotherapy-induced Diarrhea

A Sequential Single and Multiple Ascending Dose (SAD/MAD) Study of SK10 Powders in Healthy Adult Subjects

Start date: August 1, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of orally administered SK10 powders in healthy adult subjects at three dose levels, following single and multiple doses.

NCT ID: NCT06026371 Recruiting - Clinical trials for Acute Graft Versus Host Disease

Fecal Microbiota Transplantation for the Prevention of Acute Graft Versus Host Disease in Adults Undergoing Allogeneic Hematopoietic Cell Transplantation

Start date: December 12, 2023
Phase: Phase 2
Study type: Interventional

This randomized placebo-controlled double-blind phase II trial tests whether fecal microorganism (microbiota) transplantation prevents severe acute graft versus host disease in adults undergoing allogeneic hematopoietic cell transplantation (HCT). Fecal microbiota transplantation involves receiving processed fecal material orally after allogeneic HCT in order to establish a healthy gut microbiota. Gut microbiota undergoes major alterations during allogeneic HCT because of antibiotic exposures, nutritional changes, and chemotherapy administration. Establishing a healthy gut microbiota via fecal transplantation may help prevent acute graft versus host disease in patients undergoing allogeneic HCT.

NCT ID: NCT06026332 Recruiting - Bladder Cancer Clinical Trials

ADSTILADRIN Early Utilization and Outcomes in the Real World Setting in the United States

ABLE-41
Start date: September 15, 2023
Phase:
Study type: Observational

Multi-center, prospective non-interventional study to collect data on the early use of ADSTILADRIN in the US. Data will be collected from participants, caregivers and prescribing physicians in a real-world setting.

NCT ID: NCT06026319 Recruiting - Clinical trials for Mantle Cell Lymphoma

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Start date: October 26, 2023
Phase: Phase 1
Study type: Interventional

This research study involves the study of CD79b-19 CAR T cells for treating people with relapsed/refractory Non-Hodgkin Lymphoma and to understand the side effects when treated with CD79b-19 CAR T cells. This research study involves the study drugs: - CD79b-19 CAR T cells - Fludarabine and Cyclophosphamide: Standardly used chemotherapy drugs as part of lymphodepleting process

NCT ID: NCT06026280 Active, not recruiting - Distress, Emotional Clinical Trials

Depression Return to Work Intervention

DRIVEN
Start date: August 7, 2023
Phase: N/A
Study type: Interventional

This study is a randomized controlled trial to test the effectiveness of a mobile app-based program aimed to help individuals with unemployment-related emotional distress return to work.

NCT ID: NCT06026254 Active, not recruiting - Solid Tumor, Adult Clinical Trials

A Rollover Study for Subjects Who Completed Participation in IMSA101-101 Trial

Start date: September 15, 2023
Phase: Phase 1
Study type: Interventional

This is a rollover study from parent protocol IMSA101-101 for adult patients with advanced malignancies that were previously receiving IMSA101 and who would continue to receive benefit with study treatment of IMSA101 in combination with an immune checkpoint inhibitor (ICI).

NCT ID: NCT06026124 Recruiting - Clinical trials for Language Development

Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading

Start date: October 31, 2022
Phase: N/A
Study type: Interventional

Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and eventual economic well-being. Word learning is one of the principal weaknesses in these children. This project focuses on the word learning abilities of four- and five-year-old children with DLD. The goal of the project is to build on the investigators' previous work to determine whether, as has been found thus far, special benefits accrue when these children must frequently recall newly introduced words during the course of learning. In this study, the investigators seek to replicate the advantage that repeated retrieval holds over simple exposure to the words and to demonstrate an increase in children's absolute levels of learning by implementing retrieval practice in the context of a story book.