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NCT ID: NCT04942262 Completed - Complete Edentulism Clinical Trials

Oral Health-related Quality of Life and Masticatory Function After Using Denture Adhesive and Denture Liner

Start date: January 31, 2019
Phase: Phase 3
Study type: Interventional

80 complete denture (CD) wearers participated in the quasi-experimental study. Two outcomes were: 1) oral health-related quality of life (OHRQoL) assessed using the Oral Impacts on Daily Performances index, and 2) masticatory performance, determined by a peanut particle size after 20-stroke mastication. Denture retention and stability were evaluated using the Chulalongkorn University (CU)-modified Kapur method to classify the CD into acceptable or unacceptable quality. Data were collected at 3-time points: 1) at baseline (T0), 2) after a 1-month trial of denture adhesive (DA) use (T1), at which time the participants decided whether to continue using DA, and 3) 1-month after continued or discontinued using DA (T2).

NCT ID: NCT04941833 Completed - Endometrioma Clinical Trials

Desogestrel for the Preoperative Treatment of Endometrioma Compared With Placebo

Start date: June 1, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

Use of the oral desogestrel compared with placebo for preoperative treatment of endometrioma in the patient who underwent to surgery in next 3 months The result will be evaluated on cyst diameter, the associated pain and side effect of the oral desogestrel.

NCT ID: NCT04940260 Completed - Preeclampsia Clinical Trials

Soluble Factors and Renal Outcome in Preeclampsia

Start date: October 1, 2019
Phase:
Study type: Observational

Preeclampsia (PE) is an important complication of pregnancy and can lead to chronic kidney disease by causing endothelial damage and podocyte loss, Soluble forms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), sFlt1 / PlGF ratio and endoglin are the biomarkers for the differential diagnosis of preeclampsia and other diseases. We aim to explore the correlation of these biomarkers with long term renal function, blood pressure and urine albumin creatinine ratio (UACR) in PE patients.

NCT ID: NCT04939428 Completed - Clinical trials for Coronavirus Disease (COVID-19)

Study of MK-4482 for Prevention of Coronavirus Disease 2019 (COVID-19) in Adults (MK-4482-013)

MOVe-AHEAD
Start date: August 11, 2021
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess if the study medication (molnupiravir, MK-4482) will prevent symptomatic coronavirus disease 2019 (COVID-19) in adults who live with someone with confirmed COVID-19 infection. This is a phase 3, multicenter, randomized, double-blind, placebo-controlled study; half of the study participants will receive molnupiravir twice daily by mouth and the other half will receive a placebo. The primary objectives of the study are to determine if molnupiravir prevents symptomatic COVID-19 disease and to evaluate its safety and tolerability. All participants who develop COVID-19 during the study are still eligible for any COVID-19 treatment recommended by their doctor.

NCT ID: NCT04920019 Completed - Pancreas Cancer Clinical Trials

Opioid Sparing Effect of Thoracic Epidural Analgesia for Open Upper Abdominal Surgery

Start date: October 22, 2020
Phase: N/A
Study type: Interventional

This prospective randomized controlled study is aimed to determine the advantages of thoracic epidural analgesia for open upper abdominal surgery in combination with multimodal analgesia compared with no thoracic epidural analgesia on postoperative pain control. The primary outcome is total opioid consumption in postoperative 72 hours. Secondary outcomes are the success of continuous epidural analgesia or complications of this technique, pain intensity, morbidity and mortality compare to no continuous epidural analgesia.

NCT ID: NCT04914988 Completed - Hip Fractures Clinical Trials

Continuous Fascia Iliaca Compartment Block in Geriatric Hip Fracture

Start date: February 1, 2018
Phase:
Study type: Observational [Patient Registry]

The patient with hip fracture who has Numerical Rating Scale (NRS) ≥ 5 at rest or on movement will be indicated for USG FICB at Emergency Department or patient's ward. The aim of this prospective observation study was evaluated the efficacy and complications of cFICB in adult hip fracture preoperatively.

NCT ID: NCT04910412 Completed - Clinical trials for Incomplete Spinal Cord Injury

Effects of tDCS With Gait Training on Leg Performance in Incomplete Spinal Cord Injury

Start date: May 25, 2021
Phase: N/A
Study type: Interventional

This study aim to investigate the effects of anodal transcranial direct current stimulation combined with gait training for 5 consecutive session on gait performance, balance, sit to stand performance and quality of life in persons with incomplete SCI at post intervention, 1-month follow-up and 2-month follow up

NCT ID: NCT04908683 Completed - Clinical trials for Respiratory Syncytial Viruses

A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older

EVERGREEN
Start date: July 21, 2021
Phase: Phase 3
Study type: Interventional

The study will enroll up to 27,200 participants in order to demonstrate the efficacy of the active Ad26.RSV.preF-based study vaccine in the prevention of Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed Respiratory Syncytial Virus (RSV)-mediated Lower Respiratory Tract Disease (LRTD) when compared to placebo in adults aged 60 years and above.

NCT ID: NCT04905641 Completed - Thyroid Nodule Clinical Trials

The Feasibility of Bilateral Intermediate Cervical Plexus Block for Thyroidectomy/Parathyroidectomy

Start date: March 10, 2016
Phase:
Study type: Observational

The aim of this study was evaluated the feasibility of bilateral intermediate cervical plexus blockade to be anesthesia for simple thyroid/parathyroid surgery.

NCT ID: NCT04901182 Completed - Dysphagia Clinical Trials

Nutrition-dense Smoothie Diets Reduced Dysphagia Risk in the Elderly

Start date: January 8, 2019
Phase: N/A
Study type: Interventional

The investigators aimed to compare the effect of consuming high protein (23-34% energy ratio) and low carbohydrate (25-38% energy ratio) smoothie formulas vs. consuming Ensure (a conventional well-known commercial formula) on the swallowing capacity by using Flexible Endoscopic Evaluation of Swallowing (FEES) in the elderly people with dysphagia risk.