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NCT ID: NCT00936312 Completed - Hemophilia A Clinical Trials

Females With Severe or Moderate Hemophilia A or B: an International Multi-center Study

Start date: March 2008
Phase: N/A
Study type: Observational

This is a multi-center, international study designed to collect clinical, genetic and quality of life information on females with hemophilia, an inherited bleeding disorder. The study is designed to determine whether there are problems and issues unique to females with hemophilia.

NCT ID: NCT00936221 Completed - Melanoma Clinical Trials

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients

Start date: July 2009
Phase: Phase 2
Study type: Interventional

To assess the efficacy in terms of overall survival of AZD6244 in combination with dacarbazine, compared with dacarbazine alone, in first line patients with BRAF mutation positive advanced cutaneous or unknown primary melanoma

NCT ID: NCT00935662 Completed - Healthy Men Clinical Trials

A First Time in Man, Study to Assess the Safety of AZD8329 After Single Ascending Oral Doses

Start date: July 2009
Phase: Phase 1
Study type: Interventional

The primary objective for this study is to assess the safety and tolerability of AZD8329 when given as a single dose in increasing dose strength, and also to identify the highest tolerated dose for future studies.

NCT ID: NCT00934544 Completed - Myelofibrosis Clinical Trials

Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II: The COMFORT-II Trial

Start date: July 1, 2009
Phase: Phase 3
Study type: Interventional

This was an open label, randomized study comparing the efficacy and safety of randomized 2:1 Ruxolitinib tablets versus best-available therapy, as selected by the investigator. The purpose was to compare the efficacy, safety and tolerability of Ruxolitinib (INC424/INCB018424) given twice daily to the best-available therapy, in subjects with primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (PPV-MF) or post essential thrombocythemia myelofibrosis (PET-MF).

NCT ID: NCT00932893 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Start date: September 2009
Phase: Phase 3
Study type: Interventional

This is a Phase 3 trial comparing the safety and anti-tumor activity of PF-02341066 versus pemetrexed or docetaxel in patients with advanced non-small cell lung cancer with specific gene profile involving the ALK gene after failure of one previous chemotherapy regimen that included one platinum drug.

NCT ID: NCT00932451 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Start date: January 2010
Phase: Phase 2
Study type: Interventional

This is a Phase 2 trial that will evaluate the safety and efficacy of PF-02341066 in patients with advanced non-small cell lung cancer with a specific gene profile involving the ALK gene. This trial will also allow patients from a Phase 3 trial who received standard of care chemotherapy (Study A8081007) to receive PF-02341066.

NCT ID: NCT00932269 Active, not recruiting - Hepatitis B Clinical Trials

Seroimmunity 2007 and Sub Study of the Swedish Population Regarding Vaccine Preventable Disease

Sero 2007
Start date: March 2007
Phase: Phase 0
Study type: Observational

This is a randomized cross-sectional study of the Swedish population. Blood samples will be collected from a subpopulation in order to estimate the age specific sero-prevalence of the Swedish population for diseases included in the National Immunization Program (NIP), and to affirm the population's protection against polio. To be able to recommend complementary immunizations to immigrated children, a sub study focusing on foreign born teenagers will also be done and compared to children of the same age born in Sweden.

NCT ID: NCT00931294 Completed - Clinical trials for Irritable Bowel Syndrome

Saliva Testosterone Increases in Irritable Bowel Syndrome (IBS) Patients Beginning Choir Singing

Start date: May 2006
Phase: N/A
Study type: Interventional

The hypothesis was that a one-year experience of choir singing once a week is more beneficial than group discussions to saliva concentration of testosterone.

NCT ID: NCT00931190 Completed - Clinical trials for Cervical Intraepithelial Neoplasia

Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia

Start date: February 2001
Phase: N/A
Study type: Observational

The objectives are to evaluate the effectiveness of treatment of cervical intraepithelial neoplasia (CIN) by loop electrosurgical excision procedure using persistence of human papillomavirus (HPV) as outcome, and to perform a long-term follow-up on the ability of HPV testing, as compared to cytology, to predict recurrence of high-grade CIN.

NCT ID: NCT00930982 Completed - Bronchiectasis Clinical Trials

Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis

Start date: June 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to find out if bacterial load in the airways can be reduced after inhalation of ciprofloxacin for 28 days.