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NCT ID: NCT00377962 Completed - Clinical trials for Disorder Related to Cardiac Transplantation

Nordic Everolimus (Certican) Trial in Heart and Lung Transplantation

NOCTET
Start date: December 2005
Phase: Phase 4
Study type: Interventional

This study investigated whether initiation of everolimus together with reduction of calcineurin inhibitors (CNI) in maintenance heart or lung transplant patients with renal impairment would improve renal function.

NCT ID: NCT00377689 Completed - Clinical trials for Cerebrovascular Accident

Evaluation of an Intervention Program Targeted at Improving Balance and Functional Skills After Stroke

Start date: September 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate a 5-week intervention program targeted at improving balance and functional skills for people with stroke.

NCT ID: NCT00376883 Completed - Multiple Myeloma Clinical Trials

Pamidronate Prophylaxis in Multiple Myeloma 30 mg/Month Versus 90 mg/Month

Start date: January 2000
Phase: Phase 3
Study type: Interventional

Multiple myeloma is a malignant hematological disease dominated by monoclonal plasma cells in the bone marrow. Major symptoms are related to the bones due to an increased bone resorption and a decreased bone formation leading to bone pain and increased risk of fractures. The normal osteoclasts are responsible for bone degradation through stimulation from the malignant plasma cells. Bisphosphonates have been shown to inhibit the osteoclast activity but may have serious side-effects due to renal toxicity and the optimal dose have not been established. In a randomized double blinded design it is aim to compare the standard of monthly injections of 90 mg pamidronate with 30 mg. The primary end-point is physical function estimated by EORTC QLQ-C30 questionnaire at 12 months after starting the treatment in newly diagnosed treatment demanding multiple myeloma. Secondary end-points are skeletal related events, cost-utility analysis, response, response duration and survival and quality of life with respect to fatigue and pain.

NCT ID: NCT00376714 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Safety And Tolerability Study In Patients With Chronic Obstructive Pulmonary Disease

Start date: August 16, 2006
Phase: Phase 2
Study type: Interventional

GSK233705 is a high-affinity specific muscarinic receptor (mAChR) antagonist which is being developed for once daily treatment of chronic obstructive pulmonary disease (COPD). The long duration of action of GSK233705 when administered via inhalation in animal models supports the potential for use as a once-daily bronchodilator for chronic obstructive pulmonary disease.

NCT ID: NCT00375674 Completed - Kidney Neoplasms Clinical Trials

A Clinical Trial Comparing Efficacy And Safety Of Sunitinib Versus Placebo For TheTreatment Of Patients At High Risk Of Recurrent Renal Cell Cancer

S-TRAC
Start date: August 1, 2007
Phase: Phase 3
Study type: Interventional

To compare the disease free survival time and safety of sunitinib with placebo in adjuvant treatment patients at high risk of recurrent kidney cancer after surgery.

NCT ID: NCT00374855 Completed - Mild Hypertension Clinical Trials

A Study in People With Mild Hypertension

Start date: September 2006
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to test the hypothesis that LY518674, administered for 6 weeks to patients with mild hypertension, reduces Systolic Blood Pressure, compared with placebo.

NCT ID: NCT00374478 Completed - Motion Sickness Clinical Trials

Effects of Transdermal Scopolamine on Occupational Performance

Start date: April 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the effects of Transdermal scopolamine vs. placebo on ship navigation performance under simulated heavy sea conditions.

NCT ID: NCT00372125 Completed - Clinical trials for Prader-Willi Syndrome

Nordic Study on the Effects of Growth Hormone (Norditropin SimpleXx) Treatment in Adults With Prader-Willi Syndrome

Start date: April 2005
Phase: N/A
Study type: Interventional

The aim of this study is to study the effects of GH on body composition, lipid and glucose metabolism, physical performance and safety aspects in adults with PWS.The patients are randomized to either GH or placebo the first year of the study, subsequently followed by two years of GH treatment. the study is performed in Norway, Sweden and Denmark.

NCT ID: NCT00371683 Completed - Pulmonary Embolism Clinical Trials

Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

Start date: November 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep vein Thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur after knee replacement surgery and to learn how apixaban compares to enoxaparin (Lovenox®) for preventing these clots. The safety of apixaban will also be studied.

NCT ID: NCT00370344 Completed - Cholecystitis Clinical Trials

Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease

Start date: September 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The trial compares minilaparotomy (small-incision) cholecystectomy with (key-hole) laparoscopic cholecystectomy by randomly allocating patients with gallbladder disease to two groups of surgeons, each group being trained for one of the two methods.