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NCT ID: NCT06239311 Recruiting - Clinical trials for Moderate to Severe Atopic Dermatitis

Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis.

Start date: February 27, 2024
Phase: Phase 3
Study type: Interventional

Atopic dermatitis is an ongoing condition that causes skin irritation, redness, and itchiness. Treatments are usually topical - applied to the skin (e.g., moisturisers or medicated creams) - but a wider variety of systemic treatments (that target the whole body) are needed for those whose condition does not improve with topical treatments. Methotrexate, a drug approved for similar conditions such as arthritis and psoriasis, has been shown to improve atopic dermatitis. This randomised, controlled clinical trial will investigate how effective.

NCT ID: NCT06238817 Recruiting - Atopic Dermatitis Clinical Trials

A Study to Evaluate the Efficacy, and Safety Study of Ruxolitinib Cream in Adults With Moderate Atopic Dermatitis

TRuE-AD4
Start date: April 26, 2024
Phase: Phase 3
Study type: Interventional

This study is being conducted to establish the efficacy of ruxolitinib cream in participants with moderate AD who had an inadequate response to, or are intolerant to, or contraindicated to topical corticosteroid (TCS)s and topical calcineurin inhibitor (TCI)s.

NCT ID: NCT06237348 Recruiting - Clinical trials for Non-cystic Fibrosis Bronchiectasis

Simeox Therapy at Home Versus Standard of Care in NCFB Patients With CMH

Start date: October 15, 2023
Phase: N/A
Study type: Interventional

This pilot RCT will assess benefits of Simeox technology on lung function, respiratory symptoms, health-related quality of life, subjective efficiency, device adherence at home, Patient satisfaction, tolerance, safety, and telecare feasibility.

NCT ID: NCT06233630 Recruiting - Knee Osteoarthritis Clinical Trials

Erector Spinae Plane Block vs. iPACK Block With Adductor Canal Block for Total Knee Arthroplasty

Start date: March 30, 2024
Phase: Phase 4
Study type: Interventional

Effect of Erector Spinae Plane Block and iPACK block with Adductor Canal Block on pain management, and NLR and PLR following knee arthroplasty

NCT ID: NCT06233617 Recruiting - Spinal Stenosis Clinical Trials

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine Surgery

Start date: March 1, 2024
Phase: Phase 4
Study type: Interventional

Effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for spine surgery.

NCT ID: NCT06233604 Recruiting - Hip Osteoarthritis Clinical Trials

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Hip Arthroplasty

Start date: April 10, 2024
Phase: Phase 4
Study type: Interventional

Effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for hip arthroplasty

NCT ID: NCT06233565 Recruiting - Clinical trials for Ankle Injuries and Disorders

Dexamethasone vs. Dexmedetomidine for Popliteal Nerve Block in Pain Management After Pediatric Ankle and Foot Surgery

Start date: February 9, 2024
Phase: Phase 4
Study type: Interventional

Effect of perineurial dexamethasone and dexmedetomidine on popliteal nerve block duration for pediatric, ankle or foot surgery

NCT ID: NCT06233461 Recruiting - Crohn's Disease Clinical Trials

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Start date: March 5, 2024
Phase: Phase 2
Study type: Interventional

Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD). The main aim of this study is to learn if the 3 different doses of TAK-279 reduce bowel inflammation and ulcers in the bowel compared to the placebo after 12 weeks of treatment. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate any problems. An endoscopy will be used to check the bowel for inflammation. The participants will be treated with TAK-279 for 52 weeks (1 year). During the study, participants will visit their study clinic 15 times.t

NCT ID: NCT06227091 Recruiting - Muscle Strength Clinical Trials

The Effect od Beetroot Juice on Forearm Muscle Strength and Muscle EMG Activity After BloodFlow Restriction

BFR_EMG
Start date: January 10, 2024
Phase: N/A
Study type: Interventional

The primary aim of the current study is determine the effect of beetroot juice consumption on maximal grip strength and EMG muscle activity

NCT ID: NCT06226168 Recruiting - Hypoxia Clinical Trials

Effects of Normobaric Hypoxia Exercise Program on Bone Turnover Markers and Metabolism in Premenopausal Women

Start date: May 7, 2024
Phase: N/A
Study type: Interventional

The impact of a proprietary training program in normobaric hypoxia on changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women falls within the realm of physical culture for an active and healthy society. Within this context, the implementation of a project is supported aiming to: 1. Monitor, support, and promote physical development, fitness, and physical activity in society, by assessing the effects of a proprietary training program in normobaric hypoxia on changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women. 2. Develop and implement innovative methods, forms, and means of physical activation and training for individuals of various ages, by formulating general assumptions of an endurance-strength training concept under normobaric hypoxia conditions, concerning changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women. 3. Prevent injuries in physical education and sports, by designing a useful training program for osteoporosis prevention as well as for managing carbohydrate and lipid metabolism disorders in premenopausal women.