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NCT ID: NCT04424316 Completed - Clinical trials for Respiratory Tract Infection

A Trial to Evaluate the Efficacy and Safety of RSVpreF in Infants Born to Women Vaccinated During Pregnancy.

Start date: June 17, 2020
Phase: Phase 3
Study type: Interventional

This randomized, double-blinded, placebo-controlled Phase 3 study is designed to evaluate the efficacy and safety of maternal immunization with RSVpreF against medically attended lower respiratory tract illness (MA-LRTI) in infants.

NCT ID: NCT04423393 Completed - Chronic Hepatitis B Clinical Trials

Study of VIR-3434 in Healthy Volunteers and Patients With Chronic Hepatitis B Virus Infection

Start date: May 26, 2020
Phase: Phase 1
Study type: Interventional

This is a Phase 1 study in which healthy volunteers and participants with chronic HBV infection will receive VIR-3434 or placebo and will be assessed for safety, tolerability, pharmacokinetics (PK), and antiviral activity (only in participants with chronic HBV infection).

NCT ID: NCT04422431 Completed - Wilson Disease Clinical Trials

Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840

Start date: December 2, 2020
Phase: Phase 2
Study type: Interventional

The main objective of the study is to evaluate the change in liver copper (Cu) concentration following 48 weeks of treatment with ALXN1840 in adult participants with Wilson Disease (WD) who have been previously treated for at least 1 year with standard of care (that is, trientine, penicillamine, or zinc). In the Treatment Period, efficacy and safety of ALXN1840 will be assessed at Week 48.

NCT ID: NCT04419467 Completed - Clinical trials for Diabetic Kidney Disease (DKD)

Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease

Start date: September 14, 2020
Phase: Phase 2
Study type: Interventional

This phase 2a, double-blind, randomized, placebo-controlled study will assess the efficacy, safety, tolerability, and pharmacokinetics (PK), of repeat doses of CSL346 in subjects with diabetic kidney disease (DKD) and albuminuria receiving standard of care treatment.

NCT ID: NCT04416126 Completed - Clinical trials for Ornithine Transcarbamylase Deficiency

Safety, Tolerability and Pharmacokinetics of ARCT-810 in Healthy Adult Subjects

Start date: June 1, 2020
Phase: Phase 1
Study type: Interventional

Determine the safety, tolerability and pharmacokinetics of single doses of ARCT-810 in healthy adult subjects.

NCT ID: NCT04396756 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Evaluation of Efficacy and Safety of PLN-74809 in Patients With Idiopathic Pulmonary Fibrosis

Start date: March 3, 2020
Phase: Phase 2
Study type: Interventional

A Phase 2a, multicenter, 4-part, randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the safety, tolerability, and PK of once-daily treatment with PLN-74809 in participants with idiopathic pulmonary fibrosis.

NCT ID: NCT04391959 Completed - Clinical trials for Meibomian Gland Dysfunction

Evaluation of AZR-MD-001 in Patients With Meibomian Gland Dysfunction (MGD)

Start date: July 17, 2020
Phase: Phase 2
Study type: Interventional

AZ202001 is a multicenter study of AZR-MD-001 ointment and AZR-MD-001 vehicle in patients with Meibomian Gland Dysfunction (MGD)

NCT ID: NCT04380805 Completed - Clinical trials for Recurrent Cervical Cancer

A Study of AK104, a PD-1/CTLA-4 Bispecific Antibody in Subjects With Recurrent/Metastatic Cervical Cancer

Start date: July 15, 2020
Phase: Phase 2
Study type: Interventional

This is a Phase 2, global, multicenter, open label, single arm study designed to evaluate the efficacy, safety, tolerability, pharmacokinetic (PK), and immunogenicity of AK104 monotherapy in adult subjects with previously treated recurrent or metastatic cervical carcinoma.

NCT ID: NCT04378101 Completed - Anorexia Nervosa Clinical Trials

Eating Disorders Genetics Initiative

EDGI
Start date: June 12, 2020
Phase:
Study type: Observational

The overarching intention of the Eating Disorder Genetics Initiative (EDGI) is to lay the foundation for all future genomic discovery in eating disorders--anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)--by exploring both genetic and behavioral factors. To do this, information will be collected from 4000 people who have provided DNA samples for the Anorexia Nervosa Genetics Initiative (ANGI) and the same information and DNA will be collected from an additional 16,000 people. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.

NCT ID: NCT04374929 Completed - Conduction Defect Clinical Trials

Subcostal Temporary Extracardiac Pacing II Study

STEP II
Start date: July 28, 2020
Phase: N/A
Study type: Interventional

Up to 12 subjects will be enrolled (up to 8 undergoing an AtaCor Temporary Pacing System procedure) in order to evaluate initial safety and performance of the AtaCor Temporary Pacing System when used with three (3) strategies for stabilizing AtaCor Temporary Pacing System electrical measurements over a two (2) to seven (7) day period. The three treatments are (1) Negative Pressure Wound Therapy, (2) Anti-Inflammatory Glucocorticoid and (3) increased electrode spacing. A control arm with no additional treatment is also included. Safety will be evaluated through analysis of all Adverse Events. Performance will be evaluated through (1) the incidence of successful StealthTrac Lead placement using the MACH I Delivery Tool, (2) electrical performance measurements, such as pacing capture thresholds, sensed R-wave amplitudes, pacing impedance and skeletal muscle stimulation. Appropriate sensing and pacing capture will be ascertained from ECG Holter Monitor recordings during periods of in-hospital ambulation.