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NCT ID: NCT00908778 Recruiting - Clinical trials for Diabetic Retinopathy

A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects

Start date: October 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of Vitreosolve® in diabetic retinopathy patients.

NCT ID: NCT00908349 Completed - Partial Epilepsy Clinical Trials

Safety and Tolerability of OXC XR as Adjunctive Therapy in Subjects With Refractory Partial Epilepsy

Start date: June 2009
Phase: Phase 3
Study type: Interventional

Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Oxcarbazepine Extended-Release (OXC XR)

NCT ID: NCT00907296 Completed - Fracture Healing Clinical Trials

Study of Romosozumab (AMG 785) in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing

STARTT
Start date: September 2, 2009
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to investigate the effect of romosozumab compared with placebo on time to radiographic healing of fresh tibial diaphyseal fractures (fractures in the midsection of the shinbone).

NCT ID: NCT00907270 Not yet recruiting - Obesity Clinical Trials

Supplementation With Vitamin D Improves Leptin Resistance

Start date: September 2009
Phase: N/A
Study type: Interventional

Participants will be randomly assigned in one of two groups. Group A: oral supplementation with 4,000 IU of vitamin D (cholecalciferol). Group B: oral supplementation with 400 IU of vitamin D (cholecalciferol). Both treatments will be consumed daily for 6 months. Outcomes will be evaluated at baseline, three and six months. Variables related to leptin resistance will be evaluated. The main hypothesis is that vitamin D will diminish leptin resistance in overweight and obese women. If the hypothesis is confirmed, women will show a reduction in the Resting energy expenditure: serum Leptin ratio (REE: Leptin ratio), as well as a reduction of hunger, body weight, body and abdominal fat and an increase in resting energy expenditure.

NCT ID: NCT00907114 Completed - Macular Edema Clinical Trials

Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy

Start date: June 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of topic ketorolac in treatment for center point thickness secondary to panphotocoagulation in proliferative diabetic retinopathy.

NCT ID: NCT00906659 Completed - Clinical trials for Diabetic Retinopathy

Visual Function, Center Point Thickness and Macular Volume After Photocoagulation

Start date: January 2006
Phase: N/A
Study type: Observational

The purpose of this study is to correlate changes of visual function three weeks after photocoagulation for macular edema, with changes of center point thickness and macular volume.

NCT ID: NCT00906399 Completed - Clinical trials for Relapsing Multiple Sclerosis

Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis

ADVANCE
Start date: June 2009
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to determine the efficacy of peginterferon beta-1a in reducing the annualized relapse rate (ARR) in participants with relapsing multiple sclerosis (RMS) at 1 year. The secondary objectives of this study are to determine whether peginterferon beta-1a, at 1 year when compared with placebo, is effective in reducing the total number of new or newly enlarging T2 hyperintense lesions on brain magnetic resonance imaging (MRI) scans, reducing the proportion of participants who relapse, and slowing the progression of disability.

NCT ID: NCT00905593 Approved for marketing - Clinical trials for Chronic Myeloid Leukemia

Nilotinib in Adult Patients With Imatinib-resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase

ENACT
Start date: September 2008
Phase: Phase 3
Study type: Expanded Access

Multi-center, open-label, non-randomized trial to evaluate long-term safety and efficacy of nilotinib. Approximately 20 patients will be enrolled in this trial at 3 centers in Mexico, which means all ongoing patients participating on [CAMN107A2109] excluding discontinued patients. During this study, patients will receive nilotinib orally, at a dose of 400 mg b.i.d. Patients will normally receive nilotinib on an outpatient basis. This trial will have a maximum of 24 months of follow-up time.

NCT ID: NCT00903175 Completed - Clinical trials for Renal Cell Carcinoma

Efficacy and Safety Comparison of RAD001 Versus Sunitinib in the First-line and Second-line Treatment of Patients With Metastatic Renal Cell Carcinoma

RECORD-3
Start date: October 2009
Phase: Phase 2
Study type: Interventional

This study will assess the efficacy and safety of first-line RAD001 followed by second-line sunitinib versus the opposite sequence: first-line sunitinib followed by second-line RAD001 for the treatment of patients with MRCC.

NCT ID: NCT00902512 Completed - Healthy Males Clinical Trials

Study Of Bioavailability Of Two Sildenafil 100mg Oral Tablet Formulations

Start date: April 2009
Phase: Phase 4
Study type: Interventional

the pharmacokinetics of sildenafil following single doses of sildenafil CT administered with and without water is similar relative to the conventional oral tablet of sildenafil administered with water.