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NCT ID: NCT02538666 Completed - Lung Cancer Clinical Trials

An Investigational Immuno-therapy Study of Nivolumab, or Nivolumab in Combination With Ipilimumab, or Placebo in Patients With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based Chemotherapy

CheckMate 451
Start date: October 13, 2015
Phase: Phase 3
Study type: Interventional

In this study, all patients must have already completed first-line chemotherapy to treat extensive-stage disease small cell lung cancer. The purpose of this study is to show that nivolumab, or nivolumab plus ipilimumab followed by nivolumab by itself, will prolong overall survival when administered as consolidation treatment in patients that are stable or responding after chemotherapy. Patients receiving treatment will be compared with patients taking placebo.

NCT ID: NCT02537834 Completed - Clinical trials for Type 2 Diabetes Mellitus

Tofogliflozin GLP-1 Analogue Combination Trial

Start date: August 2015
Phase: Phase 4
Study type: Interventional

An open-label, multicenter study to evaluate 52-week long-term safety, tolerability and efficacy of Tofogliflozin with GLP-1 analogue treatment in type 2 diabetes mellitus.

NCT ID: NCT02537730 Completed - Myopia Clinical Trials

BIOCLEAN MPS (Multi-Purpose Solution) VII in Combination With Biofinity Lens: A Two Week Crossover Study

Start date: September 2015
Phase: N/A
Study type: Interventional

Two week, Open Label, randomized, bilateral, crossover, 1 week of daily wear in each combination (lens / disinfecting cleaning system).

NCT ID: NCT02537457 Completed - Clinical trials for Embolism, Atrial Fibrillation and Venous Thrombosis

Bioequivalence Study of Rivaroxaban

Start date: January 2014
Phase: Phase 1
Study type: Interventional

The objectives of this study are to establish the bioequivalence between rivaroxaban tablet 15 mg and rivaroxaban granule formulation 15 mg, and to assess the safety and tolerability of rivaroxaban 15 mg in healthy adult male subjects.

NCT ID: NCT02537431 Completed - Clinical trials for X-linked Hypophosphatemia

Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)

Start date: December 23, 2015
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to establish the effect of KRN23 treatment on improvement in XLH-associated osteomalacia as determined by osteoid volume (osteoid volume/bone volume, OV/BV).

NCT ID: NCT02537405 Completed - Clinical trials for Embolism, Atrial Fibrillation and Venous Thrombosis

Bioequivalence Study of Rivaroxaban in Japanese Healthy Adult Male Subjects

Start date: February 2014
Phase: Phase 1
Study type: Interventional

The objectives of this study are to establish the bioequivalence between rivaroxaban tablet 10mg and rivaroxaban granule formulation 10mg, and to assess the safety and tolerability of rivaroxaban 10mg in healthy adult male subjects.

NCT ID: NCT02537379 Completed - Clinical trials for Hepatitis C Virus Infection

Use-Results Surveillance Study of Sovaldi® Plus Copegus® in Japanese Patients With Chronic Genotype 2 Hepatitis C Virus Infection

Start date: September 15, 2015
Phase: N/A
Study type: Observational

This post-marketing surveillance (PMS) study for Sovaldi® tablets (sofosbuvir, SOF) administered in combination with Copegus® tablets (ribavirin, COPE) will evaluate the safety and efficacy of SOF administered in combination with ribavirin under real world use in Japan. Among adult patients with chronic genotype 2 hepatitis C virus (HCV) infection and treated with SOF+ribavirin in routine clinical use, the primary objective of this study is to evaluate the incidence of adverse drug reactions (ADRs) under real world settings.

NCT ID: NCT02536586 Completed - Neoplasm Clinical Trials

A Study of LY3023414 in Japanese Participants With Advanced Cancer

Start date: September 2015
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the tolerability of an investigational drug known as LY3023414 in Japanese participants with advanced cancer or cancer that has spread to another part(s) of the body. The study will also explore the safety of the drug. It will measure how much of the drug gets into the blood steam and how long the body takes to get rid of it. It will investigate anti-cancer activity.

NCT ID: NCT02536118 Active, not recruiting - Bradycardia Clinical Trials

Micra Transcatheter Pacing System Post-Approval Registry

Start date: July 2015
Phase:
Study type: Observational [Patient Registry]

Medtronic is sponsoring the Micra Registry to further confirm safety and effectiveness of the Micra Transcatheter Pacing System (Micra system) when used as intended, in "real-world" clinical practice, following commercial release. The Micra Registry is conducted within Medtronic's Product Surveillance Registry.

NCT ID: NCT02534909 Completed - Clinical trials for Paroxysmal Nocturnal Hemoglobinuria PNH

Proof of Concept Study to Assess the Efficacy, Safety and Pharmacokinetics of LFG316 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Start date: September 9, 2015
Phase: Phase 2
Study type: Interventional

To determine whether LFG316 can induce a hematological response, as measured by reduction in hemolytic activity, in patients with PNH.