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NCT ID: NCT03696771 Completed - Clinical trials for NON-breast HER2+ Malignancies

Study to Determine Safety and Dose of NJH395 in Non-breast HER2+ Advanced Cancer

Start date: December 27, 2018
Phase: Phase 1
Study type: Interventional

A first-in-human study using NJH395 in non-breast HER2-positive advanced malignancies

NCT ID: NCT03696108 Completed - Chronic Cough Clinical Trials

A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038)

Start date: October 31, 2018
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the safety of two doses of gefapixant (MK-7264) in Japanese adult participants with refractory or unexplained chronic cough.

NCT ID: NCT03694522 Completed - Gastric Cancer Clinical Trials

A Study of Bemarituzumab (FPA144) Combined With Modified FOLFOX6 (mFOLFOX6) in Gastric/Gastroesophageal Junction Cancer

FIGHT
Start date: September 14, 2018
Phase: Phase 2
Study type: Interventional

The main objective of the Phase 2 part of the study is to evaluate the efficacy of bemarituzumab (FPA144), a targeted antibody, in combination with modified FOLFOX6 compared to placebo in combination with modified FOLFOX6 in participants with advanced gastrointestinal cancer.

NCT ID: NCT03693170 Completed - Clinical trials for BRAF V600E-mutant Metastatic Colorectal Cancer

Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer

ANCHOR-CRC
Start date: January 17, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of the combination of study drugs encorafenib, binimetinib and cetuximab in patients who have BRAF V600 mutant metastatic colorectal cancer and have not received any prior treatment for their metastatic disease.

NCT ID: NCT03693131 Completed - Clinical trials for Hypertriglyceridemia

Efficacy of MND-2119 in Participants With Hypertriglyceridemia

Start date: October 27, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of MND-2119 compared to EPADEL CAPSULES 300 in participants with hypertriglyceridemia.

NCT ID: NCT03690713 Completed - Stable Angina Clinical Trials

International Collaboration of Comprehensive Physiologic Assessment

Start date: June 1, 2018
Phase:
Study type: Observational

The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).

NCT ID: NCT03689153 Completed - Healthy Clinical Trials

A Study of JNJ-63733657 in Healthy Japanese Participants

Start date: September 28, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of JNJ-63733657 following single ascending intravenous (IV) dose administration in healthy Japanese participants.

NCT ID: NCT03687684 Completed - Healthy Volunteers Clinical Trials

Phase 1 Study of TAK-831 in Healthy Adult Asian Subjects

Start date: October 9, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-831 when administered as single or multiple oral doses in healthy adult Asian participants.

NCT ID: NCT03687359 Recruiting - Dermatitis Atopic Clinical Trials

Observational Evaluation of Atopic Dermatitis in Pediatric Patients

PEDISTAD
Start date: August 15, 2019
Phase:
Study type: Observational [Patient Registry]

Primary Objectives: - To describe the characteristics of pediatric patients with moderate to severe atopic dermatitis (AD) whose disease is not adequately controlled with topical therapies or when those therapies are not medically advisable. - To evaluate the time-course of AD and selected atopic comorbidities. Secondary Objectives: - To characterize disease burden and unmet need. - To describe real-world treatment patterns (eg, dosing regimens, treatment duration, and reasons for discontinuation and/or switching). - To document the real-world effectiveness and safety of treatments.

NCT ID: NCT03685630 Completed - Epilepsy Clinical Trials

A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization

Start date: January 4, 2019
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the safety and tolerability of intravenous (iv) brivaracetam (BRV) as adjunctive therapy administered as a replacement for oral BRV at doses ranging from BRV 50 mg/day to 200 mg/day in Japanese subjects >=16 years of age with partial seizures with or without secondary generalization and to evaluate the partial seizure frequency after switching from oral administration to iv BRV.