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NCT ID: NCT03903822 Completed - Atopic Dermatitis Clinical Trials

Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic Dermatitis

Start date: May 13, 2019
Phase: Phase 2
Study type: Interventional

This study is being conducted to provide data on efficacy, safety, tolerability and PK of multiple topical formulation concentrations of PF-06700841 topical cream in the treatment of mild to moderate atopic dermatitis (AD). The study is intended to enable selection of the dose and dosing regimen (once daily [QD] vs twice daily [BID] application) for the future clinical development of topical PF-06700841.

NCT ID: NCT03902574 Completed - Healthy Adult Male Clinical Trials

Bioequivalence Study of Brexpiprazole Orally Disintegrating Tablets (ODT) 2mg

Start date: March 27, 2019
Phase: Phase 1
Study type: Interventional

To investigate the bioequivalence of brexpiprazole ODT 2 mg and brexpiprazole conventional tablet 2 mg

NCT ID: NCT03901352 Completed - Clinical trials for Central Neuropathic Pain

Study of Mirogabalin for Central Neuropathic Pain

Start date: March 12, 2019
Phase: Phase 3
Study type: Interventional

Investigate the efficacy and safety of mirogabalin in participants with central neuropathic pain in comparison to placebo

NCT ID: NCT03900715 Completed - Clinical trials for Myelodysplastic Syndromes

An Efficacy and Safety Study of Luspatercept (ACE-536) for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in Japanese Subjects Who Are Not Requiring Red Blood Cell Transfusion

Start date: May 20, 2019
Phase: Phase 2
Study type: Interventional

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is a Phase 2, multicenter, single-arm study to evaluate the efficacy, safety and Pharmacokinetics (PK) of luspatercept (ACE-536) for the treatment of anemia due to International prognostic scoring system-Revised (IPSS-R) very low, low or intermediate risk Myelodysplastic syndromes (MDS)in Japanese subjects who are not requiring Red blood cell (RBC) transfusion. The study is divided into the Screening Period, a Treatment Period and a Post-Treatment Follow up Period.

NCT ID: NCT03900598 Active, not recruiting - Clinical trials for Lymphoma, Non-Hodgkin

A Study of JNJ-67856633 in Participants With Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

Start date: April 3, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the recommended Phase 2 dose regimen or the maximum tolerated dose of JNJ-67856633 in participants with relapsed/ refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia.

NCT ID: NCT03900377 Completed - Clinical trials for Lymphoma, B-cell, Diffuse

Phase I/II Study of SyB L-0501RI in Combination With Rituximab to Treat Lymphoma

Start date: April 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

For SyB L-0501RI administered by an intravenous rapid infusion in combination with rituximab, the safety will be investigated in previously untreated patients with low-grade B-cell non-Hodgkin's lymphoma (Lg-B-NHL) or mantle cell lymphoma (MCL), and the safety and tolerability will be investigated in patients with recurrent/refractory diffuse large B-cell lymphoma (DLBCL).

NCT ID: NCT03899792 Recruiting - Soft Tissue Sarcoma Clinical Trials

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

LIBRETTO-121
Start date: June 13, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor.

NCT ID: NCT03899259 Active, not recruiting - Alopecia Areata Clinical Trials

A Study of Baricitinib (LY3009104) in Adults With Severe or Very Severe Alopecia Areata

BRAVE-AA2
Start date: July 8, 2019
Phase: Phase 3
Study type: Interventional

The reason for this study is to see if baricitinib is safe and effective in adults with severe or very severe alopecia areata (AA).

NCT ID: NCT03899155 Recruiting - Cancer Clinical Trials

Pan Tumor Rollover Study

Start date: August 9, 2019
Phase: Phase 2
Study type: Interventional

Main Objective of this study is to examine long-term safety of nivolumab monotherapy including combinations and other cancer therapies in various tumor types.

NCT ID: NCT03898791 Completed - Clinical trials for Small Cell Lung Cancer

A Study of LY3295668 Erbumine in Participants With Extensive-stage Small-Cell Lung Cancer

Start date: July 16, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the recommended phase 2 dose of LY3295668 erbumine in participants with platinum-sensitive, extensive-stage small-cell lung cancer.