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NCT ID: NCT02825264 Active, not recruiting - Open Angle Glaucoma Clinical Trials

STAR-LIFE Registry: STARflo Glaucoma Implant Clinical Experience Program

Start date: July 2016
Phase:
Study type: Observational

STARflo is a novel suprachoroidal Glaucoma Drainage Device (GDD), bleb-free, exhibiting anti-fibrotic properties. Release of this CE Marked implant has been limited to leading Glaucoma Centers in Europe.

NCT ID: NCT02782663 Active, not recruiting - Clinical trials for Crohn's Disease (CD)

A Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Participants With Crohn's Disease

Start date: May 18, 2016
Phase: Phase 2
Study type: Interventional

This is a open-label extension (OLE) study designed to evaluate the long-term efficacy, safety, and tolerability of Upadacitinib (ABT-494).

NCT ID: NCT02763319 Active, not recruiting - Clinical trials for Diffuse Large B-cell Lymphoma

A Trial to Evaluate the Efficacy and Safety of Tafasitamab With Bendamustine (BEN) Versus Rituximab (RTX) With BEN in Adult Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

B-MIND
Start date: June 2016
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of the study is to compare the safety and efficacy of Tafasitamab with BEN versus RTX with BEN in adult patients with relapsed of refractory DLBCL.

NCT ID: NCT02759094 Active, not recruiting - GERD Clinical Trials

Evaluation of Safety and Effectiveness of the RefluxStop Device in the Management of GERD

Start date: December 2016
Phase: N/A
Study type: Interventional

Prospective, open-label, multi-centre, single arm treatment only trial to evaluate the safety and effectiveness of RefluxStop for the treatment of GERD. The used medical device "RefluxStop" is an implantable single use sterile device to ensure maintenance of gastro oesophageal junction (GEJ) in an intra-abdominal position to reduce or eliminate GERD.

NCT ID: NCT02752737 Active, not recruiting - Atrial Fibrillation Clinical Trials

Cryo Global Registry

Start date: May 2016
Phase:
Study type: Observational [Patient Registry]

Cryo Global Registry a prospective, global, multi-center, observational Post-Market Registry

NCT ID: NCT02748460 Active, not recruiting - Uterine Fibroids Clinical Trials

Non-interventional Study to Evaluate Long Term Safety, Prescription Management Patterns of Esmya in a Long Term Setting

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Start date: December 2015
Phase:
Study type: Observational

This is a multi-centre, multinational, prospective, non-interventional study in females with a diagnosis of moderate to severe uterine fibroids, and for whom a treatment with Esmya in a long term manner is planned, and in subjects who were previously exposed to UPA in the long term Phase III studies.

NCT ID: NCT02743494 Active, not recruiting - Advanced Cancer Clinical Trials

An Investigational Immuno-therapy Study of Nivolumab or Placebo in Participants With Resected Esophageal or Gastroesophageal Junction Cancer

CheckMate 577
Start date: July 14, 2016
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to determine whether Nivolumab will improve disease-free survival compared with placebo.

NCT ID: NCT02719613 Active, not recruiting - Multiple Myeloma Clinical Trials

Continuing Treatment for Participants Who Have Participated in a Prior Protocol Investigating Elotuzumab

Start date: July 15, 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to continue to provide elotuzumab and/or other study drugs to participants who have participated on a prior protocol investigating elotuzumab who are not able to receive commercial drug supply.

NCT ID: NCT02711553 Active, not recruiting - Metastatic Cancer Clinical Trials

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Start date: May 19, 2016
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to evaluate the efficacy and safety of ramucirumab or merestinib or placebo plus cisplatin and gemcitabine in participants with advanced or metastatic biliary tract cancer.

NCT ID: NCT02700100 Active, not recruiting - Clinical trials for Congenital Heart Disease

Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract Reconstruction

Start date: June 2016
Phase: N/A
Study type: Interventional

The study is a prospective, non-randomised, open label clinical study to assess the safety of the Bioabsorbable Pulmonary Valved (PV) conduit (PV-001) in subjects > 2 years and < 22 years of age, undergoing Right Ventricular Outflow Tract (RVOT) reconstruction. It is a first in man feasibility study which will include 10-12 patients in up to 6 sites in Europe. The primary objective of the study is to assess the survival rate of subjects at 6 months following implantation of the Bioabsorbable Pulmonary Valved Conduit (PV-001). Secondary objectives: 1. The survival rate of subjects at 12 months following implantation of the Bioabsorbable Pulmonary Valved Conduit (PV-001) 2. The percentage of conduit failure at 6 months and 12 months, where conduit failure includes the need for reintervention or reoperation. 3. The pressure gradient across the pulmonary valve will have an acceptable level at 12 months follow up. 4. The pulmonary regurgitation measured will not exceed a moderate grading at 12 months follow up. 5. To evaluate the usability of the Bioabsorbable Pulmonary Valved Conduit (PV-001) during the surgical procedure, using exploratory parameters Long term safety will be assessed up to 60 months post implantation.