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NCT ID: NCT01590459 Completed - Clinical trials for Rheumatoid Arthritis

24-week Study With Open Label Extension of VX-509, an Oral JAK3 Inhibitor, in Subjects Taking Methotrexate

Start date: April 2012
Phase: Phase 2
Study type: Interventional

This study is designed to evaluate the safety and efficacy of VX-509, an oral JAK3 inhibitor, for treatment of subjects with active RA who have had an inadequate response to Methotrexate.

NCT ID: NCT01588184 Completed - Neoplasms Clinical Trials

An Extension Study to Provide Continued Bevacizumab Therapy to Participants With Solid Tumors Who Were Previously Enrolled in a Roche/Genentech Sponsored Study

Start date: July 13, 2012
Phase: Phase 4
Study type: Interventional

This single-arm, open-label, multicenter extension study will provide continued bevacizumab therapy to participants with solid tumors who were previously enrolled in a Roche/Genentech sponsored study and who derived benefit from the bevacizumab therapy. Participants will receive the same dose and regimen of bevacizumab as used in the previous parent trial and continue this treatment until progression of disease or unacceptable toxicity, withdrawal of consent or death whichever occurs first.

NCT ID: NCT01585649 Completed - Clinical trials for Ewing Family of Tumors, Rhabdomyosarcoma

PK/PD of XM22 in Children With Ewing Family of Tumors or Rhabdomyosarcoma

Start date: July 2012
Phase: Phase 1
Study type: Interventional

This is a Phase I, open label study aimed at assessing the pharmacokinetics, pharmacodynamics, the efficacy, safety, and tolerability of a single injection of XM22 in children with Ewing family of tumors or rhabdomyosarcoma scheduled to receive chemotherapy (CTX)

NCT ID: NCT01584986 Completed - Clinical trials for Critical Limb Ischemia

Autologous Angiogenic Cell Precursors (ACPs) for the Treatment of Peripheral Artery Disease

Start date: May 2008
Phase: Phase 2
Study type: Interventional

Regeneration of the occluded peripheral arteries by autologous stem cell therapy is an emerging treatment modality for no-option patients with peripheral artery disease (PAD). The purpose of this study was to assess safety and efficacy of ex vivo expanded, peripheral blood-derived, autologous angiogenic cell precursors (ACPs) in no-option PAD patients.

NCT ID: NCT01583738 Completed - Acute Vertigo Clinical Trials

Effect of V0251 in Acute Vertigo

Start date: April 2012
Phase: Phase 2
Study type: Interventional

Assessment of efficacy and tolerance of a new anti-dizziness drug in acute vertigo.

NCT ID: NCT01583374 Completed - Clinical trials for Ankylosing Spondyloarthritis

Study of Apremilast to Treat Subjects With Active Ankylosing Spondylitis

POSTURE
Start date: May 2, 2012
Phase: Phase 3
Study type: Interventional

Apremilast is a new, orally available, small molecule drug that specifically inhibits phosphodiesterase 4 (PDE4), an enzyme that modulates inflammatory cytokines. This clinical study tests whether apremilast can improve the signs and symptoms of ankylosing spondylitis.

NCT ID: NCT01583218 Completed - Clinical trials for Venous Thromboembolism (VTE)

Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)

APEX
Start date: March 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate whether extended prophylaxis with oral betrixaban can prevent blood clots in the leg and lung that sometime occur in patients hospitalized for an acute medical illness and to compare these results with standard of care enoxaparin. The safety of betrixaban will also be studied.

NCT ID: NCT01582815 Completed - Clinical trials for Major Depressive Disorder

A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptoms

Start date: September 2012
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and overall safety and tolerability of treatment with adjunctive JNJ-40411813 compared to placebo in patients with MDD with anxiety symptoms being treated with an antidepressant.

NCT ID: NCT01582503 Completed - Asthma Clinical Trials

A Study of MEMP1972A in Patients With Allergic Asthma Inadequately Controlled on Inhaled Steroids And A Second Controller (COSTA)

Start date: April 2012
Phase: Phase 2
Study type: Interventional

This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of 3 dosing regimens of MEMP1972A in patients with allergic asthma who remain inadequately controlled on chronic therapy with high dose inhaled corticosteroids and a second controller medication.Patients will be randomized to 4 Arms to receive subcutaneous repeating dose of either MEMP1972A 150 mg, 300 mg, or 450 mg, or placebo. Patients will continue their usual asthma medication throughout the study. Anticipated time on study treatment is 36 weeks, with a 48-week follow-up.